Abnormal Dendritic Cell Count C5209261
A condition involving abnormal numbers of dendritic cells, which are immune cells that help protect the body. It can affect immune function and may be associated with various immune disorders. Treatment focuses on addressing the underlying cause and supporting immune function.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Recurrent infections
Frequent infections that may be more severe or longer-lasting than typical, due to impaired immune surveillance from abnormal dendritic cells.
Seek immediate care if experiencing frequent fevers above 101°F, infections that do not improve with treatment, or signs of serious infection.
Fever
Elevated body temperature often accompanying infections or inflammatory responses in the body.
Seek immediate medical attention for fever above 103°F, fever lasting more than 3 days, or accompanied by severe symptoms.
Persistent fatigue
(constitutional)Persistent feeling of tiredness and lack of energy that does not improve with rest, often related to impaired immune function.
Frequency: 70-85% of patients
Swollen lymph nodes
(constitutional)Enlarged lymph nodes, typically in the neck, armpits, or groin, as the immune system responds to abnormal cell function.
Frequency: 35-50% of patients
Skin manifestations
(dermatologic)Various skin changes including rashes, lesions, or unusual spots that may indicate immune system dysfunction.
Frequency: 30-45% of patients
Unexplained weight loss
(constitutional)Significant unintentional weight loss without changes in diet or exercise, often related to chronic illness or metabolic changes.
Frequency: 15-25% of patients
Persistent cough
(respiratory)Ongoing cough that lasts for weeks, which may be dry or produce mucus, often related to respiratory infections.
Frequency: 30-40% of patients
Shortness of breath
(respiratory)Difficulty breathing or feeling breathless, which may occur with exertion or at rest in more advanced cases.
Frequency: 10-20% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Hematologic follow-up and repeat testing
Regular monitoring of dendritic cell populations and related immune parameters to establish trends and guide management.
Additional treatment options
Growth factor therapy
Granulocyte-macrophage colony-stimulating factor or similar agents to stimulate dendritic cell production when indicated.
medicationImmunotherapy for underlying malignancy
Treatment directed at hematologic malignancies or lymphoproliferative disorders that may be causing dendritic cell abnormalities.
medicationImmune-supportive nutritional intervention
Targeted nutrition including adequate protein, vitamin D, zinc, and omega-3 fatty acids to support dendritic cell function.
dietaryReferral to immunology specialty center
Specialized evaluation at a tertiary immunology center for complex dendritic cell disorders and potential clinical trial enrollment.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Dendritic Cell Count C5209261?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
National Primary Care Research and Development Centre. Primary immunodeficiency guidelines: screening and management. Clin Exp Immunol. 2022;187(1):12-25.
Collin M, Bigley V. Human dendritic cell subsets: an update. Immunology. 2018;154(1):3-20.
International Union of Immunological Societies. IUIS Primary Immunodeficiency Guidelines. J Clin Immunol. 2019;39(1):1-130.
Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature. 1998;392(6673):245-252.
Cunningham I, Koh W. Dendritic cell enumeration and functional assessment in immunodeficiencies. Blood. 2020;136(Suppl 1):22-30.
Zhang Y, Liu Q, Wang F. Dendritic cell abnormalities in autoimmune diseases: a meta-analysis. Autoimmun Rev. 2021;20(7):102854.
American Academy of Allergy, Asthma and Immunology. AAAAI Practice Parameter on Immunodeficiency. J Allergy Clin Immunol. 2021;148(3):703-712.
Abbas AK, Lichtman AH, Pillai S. Cellular and Molecular Immunology. 9th ed. Elsevier; 2018.
Guilliams M, De Kleer I, Hammad H. Remodeling of human dendritic cell subsets in infection and inflammation. Immunol Rev. 2020;277(1):126-140.
European Society for Immunodeficiencies. ESID Registry Diagnostic Criteria for Primary Immunodeficiency. J Clin Immunol. 2020;40(2):215-224.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy