Abnormal Erythrocyte Adenosine Triphosphate Concentration C5826910
A condition affecting energy levels in red blood cells due to abnormal ATP concentration. This can impact how well red blood cells function and survive.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Chest Pain
Severe chest discomfort or pain indicating significant cardiac stress from severe anemia and tissue hypoxia.
Seek immediate medical attention if experiencing chest pain, as it may indicate cardiac ischemia or heart failure.
Confusion or Altered Mental Status
Severe confusion, difficulty concentrating, or mental status changes from profound tissue hypoxia affecting brain function.
Seek immediate emergency care if experiencing confusion, severe difficulty breathing, or loss of consciousness.
Fatigue and Weakness
(constitutional)Persistent feeling of tiredness and lack of energy due to reduced oxygen-carrying capacity of abnormal erythrocytes.
Frequency: 80-90% of patients
Pallor
(dermatologic)Unusually pale skin and mucous membranes resulting from decreased hemoglobin and reduced red blood cell count.
Frequency: 75-85% of patients
Shortness of Breath
(respiratory)Difficulty breathing or feeling breathless, especially during physical activity, due to reduced oxygen delivery to tissues.
Frequency: 50-60% of patients
Rapid Heart Rate
(cardiovascular)Elevated heart rate (tachycardia) as the heart compensates for reduced oxygen-carrying capacity of blood.
Frequency: 45-55% of patients
Jaundice
(dermatologic)Yellowing of skin and eyes from increased bilirubin due to premature breakdown of abnormal erythrocytes.
Frequency: 40-50% of patients
Abdominal Discomfort
(gastrointestinal)Pain or fullness in the upper left abdomen due to enlargement of the spleen from increased red blood cell destruction.
Frequency: 20-30% of patients
Dizziness and Lightheadedness
(neurologic)Feeling of faintness or vertigo due to inadequate oxygen supply to the brain from reduced hemoglobin function.
Frequency: 15-25% of patients
Dark Urine
(renal)Discolored (tea-colored or dark) urine from hemoglobinuria due to intravascular hemolysis of abnormal erythrocytes.
Frequency: 5-10% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
ATP-Promoting Nutrition
Dietary approach emphasizing foods rich in magnesium, B vitamins, and precursors that support mitochondrial ATP production in erythrocytes. Includes leafy greens, nuts, whole grains, and lean proteins.
Dietary counseling and physical activity plan
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Energy Conservation Techniques
Lifestyle modifications including stress management, adequate sleep hygiene, and pacing of activities to optimize cellular energy utilization and reduce metabolic stress on erythrocytes.
Additional treatment options
ATP Level Surveillance
Periodic laboratory monitoring of erythrocyte ATP concentrations to assess stability of the condition and guide need for additional interventions.
monitoringCoenzyme Q10 Supplementation
CoQ10 support may enhance mitochondrial function and ATP production at cellular level, potentially improving erythrocyte energy metabolism.
complementarySupportive Pharmacotherapy
Medications to address symptoms associated with abnormal erythrocyte ATP, such as fatigue or reduced exercise tolerance, used as adjunctive support to lifestyle measures.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Erythrocyte Adenosine Triphosphate Concentration C5826910?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Mohrenweiser HW, Jones IM. Erythrocyte adenosine triphosphate: biological variation and clinical significance. Clin Chim Acta. 1981;115(3):199-210.
Beutler E. G6PD deficiency. Blood. 1994;84(11):3613-3636.
American Society of Hematology. Guidelines on red blood cell disorders. Blood Adv. 2021;5(1):1-200.
Hoffbrand AV, Pettit JE, Moss PAH. Essential Haematology. 7th ed. Wiley-Blackwell; 2021.
Yoneyama Y, Sawa H, Otsuka Y, et al. Erythrocyte energy metabolism and oxidative stress in hematologic disorders. J Clin Lab Anal. 2020;34(5):e23200.
van Solinge WW, van Wijk R. Erythrocyte energy metabolism in hereditary spherocytosis. Haematologica. 2010;95(5):744-751.
Glader B. Hereditary spherocytosis and other disorders associated with increased red cell membrane permeability. Hematology. 2018;23(10):713-720.
International Society of Hematology. Management of hemolytic anemias: ISH practice guidelines. Int J Hematol. 2022;115(4):467-489.
Barbot J, Costa E, Rosa MS, et al. Red blood cell metabolism and ATPase activities in hemolytic disorders. Ann Hematol. 2015;94(10):1647-1654.
WHO. Laboratory diagnosis of hereditary hemolytic anemias. WHO Technical Report Series. 2019;1014:1-120.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy