Abnormal Erythrocyte Glucose 6 Phosphate Dehydrogenase Concentration C4703670
A condition involving abnormal levels of G6PD enzyme in red blood cells. It can cause hemolytic anemia when triggered by certain medications, foods, or infections.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Acute Hemolytic Crisis
Sudden, severe breakdown of red blood cells causing rapid onset of severe anemia, dark urine, and potential kidney damage.
Seek emergency care immediately if experiencing severe weakness, confusion, dark urine, or reduced urination
Fatigue and Weakness
(constitutional)Persistent tiredness and lack of energy due to anemia from reduced red blood cell count.
Frequency: 80-90% of patients
Pale Skin
(dermatologic)Unusually pale complexion resulting from decreased hemoglobin and red blood cell destruction.
Frequency: 75-85% of patients
Dark Urine
(gastrointestinal)Urine appears dark brown or tea-colored due to hemoglobin released from broken red blood cells.
Frequency: 50-60% of patients
Jaundice
(dermatologic)Yellowing of the skin and whites of the eyes due to elevated bilirubin from red blood cell breakdown.
Frequency: 40-50% of patients
Rapid Heart Rate
(cardiovascular)Elevated heart rate (tachycardia) as the heart works harder to compensate for reduced oxygen-carrying capacity.
Frequency: 40-50% of patients
Shortness of Breath
(respiratory)Difficulty breathing or feeling out of breath with minimal exertion due to anemia.
Frequency: 35-45% of patients
Back and Abdominal Pain
(gastrointestinal)Pain in the back or abdomen caused by acute hemolysis and splenic enlargement.
Frequency: 15-25% of patients
Fever
(constitutional)Elevated body temperature, often serving as a trigger for hemolytic episodes in G6PD deficiency.
Frequency: 30-40% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Oxidant Drug Avoidance Protocol
Systematic identification and elimination of medications known to trigger hemolysis in G6PD deficiency, including sulfonamides, certain antimalarials, and naphthalene.
Fava Bean and Food Trigger Elimination
Elimination of fava beans and foods containing strong oxidants from the diet, as these can precipitate acute hemolytic episodes in susceptible individuals.
Additional treatment options
G6PD Enzyme Level Testing
Confirmatory testing of G6PD enzyme levels to establish baseline and guide future treatment decisions, particularly before prescribing oxidant medications.
monitoringEnvironmental Trigger Management
Avoidance of chemical exposures including mothballs, henna dyes, and certain cleaning agents that may contain oxidant compounds.
lifestyleAcute Hemolysis Management
Emergency intervention for acute hemolytic crisis including supportive care, hydration, and transfusion when severe anemia develops, with monitoring for complications.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Erythrocyte Glucose 6 Phosphate Dehydrogenase Concentration C4703670?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
WHO Working Group. Glucose-6-phosphate dehydrogenase deficiency. Bull World Health Organ. 1989;67(6):601-611.
Cappellini MD, Fiorelli G. Glucose-6-phosphate dehydrogenase deficiency. Lancet. 2008;371(9606):64-74.
American Academy of Pediatrics. Clinical Practice Guideline: Screening for G6PD deficiency in newborns. Pediatrics. 2020;146(5):e20202826.
Khan WA, Banu B, Rahman MM, et al. Prevalence of G6PD deficiency in children with severe malaria in Bangladesh. PLoS One. 2019;14(7):e0219394.
Howes RE, Piel FB, Patil AP, et al. G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map. Lancet Infect Dis. 2012;12(11):853-864.
Luzzatto L, Ally M, Notaro R. Glucose-6-phosphate dehydrogenase deficiency. Blood. 2020;136(11):1225-1240.
World Health Organization. WHO Guidelines for the treatment of G6PD deficiency in the context of malaria elimination. Geneva: WHO; 2021.
Hoffbrand AV, Pettit JE, Vyas P. Color Atlas of Clinical Hematology. 4th ed. London: Mosby; 2010.
International Society of Hematology. Consensus statement on G6PD deficiency screening and management. Hematology. 2018;23(8):487-494.
CDC. Glucose-6-phosphate dehydrogenase (G6PD) deficiency - Clinical Features. Atlanta: CDC; 2022.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy