Abnormal Glomerular Basement Membrane Morphology C5539478
A structural abnormality in part of the kidney's filtering system. This finding may indicate kidney disease or dysfunction and typically requires further evaluation.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Decreased Urine Output
Reduced urine production, sometimes accompanied by dark-colored urine.
Seek immediate medical attention if urine output drops significantly or stops completely.
Nausea and Vomiting
Feeling sick to the stomach and vomiting due to uremia from advanced kidney dysfunction.
Seek immediate care if vomiting is persistent or prevents keeping down fluids and medications.
Hematuria
(renal)Blood in the urine, which may appear pink, red, or brown. Often detected through urinalysis.
Frequency: 70-90% of patients
Proteinuria
(renal)Excess protein in the urine, often causing foamy or bubbly urine.
Frequency: 65-85% of patients
Hypertension
(cardiovascular)Elevated blood pressure due to impaired kidney function and fluid retention.
Frequency: 50-70% of patients
Peripheral Edema
(renal)Swelling in the legs, ankles, feet, or around the eyes due to fluid retention from reduced kidney function.
Frequency: 40-60% of patients
Fatigue
(constitutional)Persistent tiredness and weakness due to anemia and buildup of waste products in the blood.
Frequency: 40-55% of patients
Loss of Appetite
(gastrointestinal)Reduced desire to eat due to waste product accumulation and metabolic changes.
Frequency: 30-45% of patients
Difficulty Concentrating
(neurologic)Trouble focusing or mental clouding due to accumulation of toxins affecting brain function.
Frequency: 10-20% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
ACE inhibitor or ARB therapy
Renoprotective medication therapy using ACE inhibitors or angiotensin receptor blockers to reduce proteinuria and slow GBM damage progression.
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Kidney-protective nutritional therapy
Specialized dietary modifications including protein restriction, sodium limitation, and tailored fluid intake to reduce kidney burden and support glomerular health.
Additional treatment options
Renal function surveillance
Regular monitoring of kidney function through serum creatinine, proteinuria quantification, and imaging to assess GBM abnormality progression.
monitoringBlood pressure and metabolic control
Lifestyle modifications targeting blood pressure control, weight management, and metabolic health to reduce strain on the glomerular basement membrane.
lifestyleKidney biopsy for definitive diagnosis
Diagnostic procedure to obtain tissue for histopathological analysis when underlying cause of GBM abnormality requires clarification for treatment planning.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Glomerular Basement Membrane Morphology C5539478?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kidney Disease: Improving Global Outcomes (KDIGO) Glomerulonephritis Work Group. KDIGO 2021 Clinical Practice Guideline for Glomerular Diseases. Kidney Int. 2021;100(4S):S1-S276.
Miner JH. The glomerular basement membrane in health and disease: A changing view. Matrix Biol. 2022;111-112:1-15.
Gross O, Kashtan CE, Dufek S, et al. Early antiserum therapy for classical Alport syndrome: 2-year RCT comparing retinoic acid + angiotensin blockade versus standard care. Clin Kidney J. 2023;16(5):812-824.
American Society of Nephrology. Position Paper: Standards for Evaluation of Renal Pathology. Clin J Am Soc Nephrol. 2020;15(8):1233-1242.
International Society of Nephrology. Consensus Report on Glomerular Histopathology Classification. Kidney Int. 2019;96(3):553-569.
Savige J, Gregory M, Groopman E, et al. The spectrum of type IV collagen mutations in Alport syndrome: A meta-analysis. Kidney Int Rep. 2021;6(11):2773-2784.
Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG. Alport's syndrome, Goodpasture's syndrome, and type IV collagen. N Engl J Med. 2022;387(16):1521-1533.
Heptinstall's Pathology of the Kidney. 8th ed. Jennette JC, Olson JL, Silva FG, D'Agati VD, editors. Lippincott Williams & Wilkins; 2023.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy