Abnormal Glomerular Filtration Rate C0854050
This describes structural changes in the material between cells in kidney filtering units. It may indicate various kidney disorders and generally requires investigation to determine the specific condition and guide appropriate management.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Shortness of breath
Difficulty breathing, especially with activity, caused by fluid accumulation in the lungs due to kidney dysfunction.
Seek immediate care if shortness of breath occurs at rest or worsens suddenly
Confusion or difficulty concentrating
Mental confusion, difficulty focusing, or memory problems caused by toxin accumulation affecting brain function.
Seek immediate care if confusion comes on suddenly or is severe
Fatigue and weakness
(constitutional)Persistent tiredness and lack of energy due to toxin buildup when kidneys cannot filter waste effectively.
Frequency: 70-80% of patients
Changes in urination
(renal)Altered urine output or appearance, including foamy urine, blood in urine, or increased/decreased frequency.
Frequency: 60-75% of patients
Swelling (edema)
(cardiovascular)Fluid retention causing swelling in legs, ankles, feet, or around the eyes due to reduced kidney function.
Frequency: 50-60% of patients
Nausea and vomiting
(gastrointestinal)Feeling sick to the stomach and vomiting due to waste accumulation in the bloodstream.
Frequency: 40-50% of patients
Itchy skin (pruritus)
(dermatologic)Severe itching caused by mineral and toxin buildup under the skin when kidneys fail to filter properly.
Frequency: 20-30% of patients
Loss of appetite
(gastrointestinal)Decreased desire to eat due to nausea, altered taste, or the feeling of fullness from fluid retention.
Frequency: 45-55% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Blood Pressure Management
Lifestyle modifications including reduced sodium intake, regular aerobic exercise, stress reduction, and smoking cessation to achieve optimal blood pressure control and reduce glomerular stress.
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
RAAS Inhibitor Therapy
Pharmacological intervention using renin-angiotensin-aldosterone system inhibitors to reduce intraglomerular pressure and provide renal protection. Regular monitoring of kidney function and electrolytes is essential during treatment.
Additional treatment options
Protein Intake Modification
Individualized dietary protein restriction to decrease glomerular hyperfiltration and slow disease progression. Protein intake is tailored based on baseline GFR and nutritional status.
dietaryRegular GFR Surveillance
Scheduled laboratory assessment of glomerular filtration rate using creatinine-based equations or cystatin C measurements to track disease progression and treatment response.
monitoringCoenzyme Q10 Supplementation
Antioxidant supplementation to support mitochondrial function in renal tissue and potentially reduce oxidative stress-related glomerular damage. Evidence remains supportive rather than definitive.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Glomerular Filtration Rate C0854050?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney International Supplements. 2012;3(1):1-150.
National Kidney Foundation. K/DOQI Clinical Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification, and Stratification. American Journal of Kidney Diseases. 2002;39(2 Suppl 1):S1-266.
Levey AS, Stevens LA, Schmid CH, et al. A New Equation to Estimate Glomerular Filtration Rate. Annals of Internal Medicine. 2009;150(9):604-612.
Schaeffner ES, Ebert N, Delanaye P, et al. Two Novel Equations to Estimate Kidney Function in Persons Aged 70 Years or Older. Annals of Internal Medicine. 2012;157(7):471-481.
National Kidney Foundation. KDOQI Clinical Practice Guideline for Diabetes and CKD: 2020 Update. American Journal of Kidney Diseases. 2020;76(5):669-683.
Levey AS, Coresh J. Chronic Kidney Disease. The Lancet. 2012;379(9811):165-180.
Inker LA, Eneanya ND, Coresh J, et al. New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race. New England Journal of Medicine. 2021;385(19):1737-1749.
Kidney Disease: Improving Global Outcomes (KDIGO) Lipid Work Group. KDIGO Clinical Practice Guideline for Lipid Management in Chronic Kidney Disease. Kidney International Supplements. 2013;3(3):259-305.
Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group. KDIGO 2021 Clinical Practice Guideline for Glomerular Diseases. Kidney International. 2021;100(4):S1-276.
US Food and Drug Administration. Guidance for Industry: Pharmacokinetics in Patients with Impaired Renal Function - Study Design, Data Analysis, and Impact on Dosing and Labeling. 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy