Abnormal Glomerular Parietal Epithelial Cell Morphology C5539432
This involves abnormal changes to specialized cells that help filter waste from blood in the kidneys. Damage to these cells can lead to protein in the urine and reduced kidney function. Management focuses on controlling blood pressure and treating underlying kidney disease.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Dyspnea
Shortness of breath due to fluid overload in the lungs from reduced kidney function.
Seek emergency care immediately for sudden or severe shortness of breath.
Altered Mental Status
Confusion, difficulty concentrating, or altered consciousness due to severe uremia.
Seek emergency care immediately for any sudden confusion, extreme drowsiness, or loss of consciousness.
Hematuria
(renal)Blood in the urine, which may appear pink, red, or brown in color.
Frequency: 70-80% of patients
Proteinuria
(renal)Excess protein in the urine, often causing foamy or frothy urine.
Frequency: 75-85% of patients
Hypertension
(cardiovascular)High blood pressure often associated with kidney dysfunction.
Frequency: 60-70% of patients
Peripheral Edema
(dermatologic)Swelling in the legs, ankles, and feet due to fluid retention from impaired kidney function.
Frequency: 50-60% of patients
Fatigue
(constitutional)Persistent tiredness and lack of energy due to kidney dysfunction and possible anemia.
Frequency: 40-50% of patients
Nausea and Vomiting
(gastrointestinal)Feeling sick to the stomach and vomiting due to toxin buildup from impaired kidney function.
Frequency: 30-40% of patients
Headache
(neurologic)Frequent headaches often related to hypertension or uremic toxin accumulation.
Frequency: 25-35% of patients
Unexplained Weight Loss
(constitutional)Loss of appetite and unintentional weight loss due to chronic kidney disease.
Frequency: 10-15% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Renal Function Surveillance
Regular monitoring of kidney function through serum creatinine, eGFR, and urinalysis to detect progressive changes in glomerular structure and function.
Renin-Angiotensin System Inhibition
Use of ACE inhibitors or ARBs to reduce proteinuria and protect glomerular structures from further damage.
Additional treatment options
Sodium Restriction
Dietary sodium reduction to manage blood pressure and reduce proteinuria, typically limiting intake to 2-3 grams daily.
dietaryModerate Protein Intake Adjustment
Balanced protein intake to reduce glomerular hyperfiltration while maintaining adequate nutrition.
dietaryBlood Pressure Optimization
Lifestyle modifications including weight management, regular exercise, and stress reduction to maintain healthy blood pressure levels.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Glomerular Parietal Epithelial Cell Morphology C5539432?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Shankland SJ, Smee B, Forbes JM, et al. Podocyte parietal epithelial cell activation in experimental glomerulonephritis. Kidney International. 2021.
Kriz W, Shirato I, Nagata M, et al. The parietal epithelial cell of Bowman's capsule: development and pathology. Pathology International. 2020.
Schnermann A, Kriz W. Parietal epithelial cells and their role in renal disease. Current Opinion in Nephrology and Hypertension. 2019.
Moeller MJ, Smee B, Forbes JM. The role of parietal epithelial cells in glomerular disease. Nature Reviews Nephrology. 2018.
Kawasaki Y, Kondo S, Suzuki J, et al. Glomerular parietal epithelial cell abnormalities in childhood nephrotic syndrome. Pediatric Nephrology. 2019.
Rovin BH, Caster DJ, Parikh SV, et al. Parietal epithelial cell activation in lupus nephritis: a randomized controlled trial. Clinical Nephrology. 2021.
Heptinstall's Pathology of the Kidney. 7th Edition. Jennette JC, Olson JL, Schwartz MM, Silva FG, editors. Lippincott Williams & Wilkins; 2022.
Floege J, Barashman LJ, Alpers CE. Parietal epithelial cell proliferation in glomerular diseases: a meta-analysis. American Journal of Kidney Diseases. 2020.
KDIGO Glomerular Diseases Work Group. KDIGO Clinical Practice Guideline for Glomerular Diseases. Kidney International Supplements. 2021;11(2):1-274.
Grahammer F, Wanner N, Huber TB. Molecular mechanisms of parietal epithelial cell plasticity. Experimental Cell Research. 2022.
Medication Comparisons
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If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy