Abnormal Glucose 6 Phosphate Dehydrogenase Level In Tissue C4703671
A condition affecting red blood cell enzyme levels that can lead to anemia when triggered by certain medications, foods, or infections.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Severe Hemolytic Crisis
Life-threatening episode of rapid and severe red blood cell destruction leading to acute anemia, organ failure, and potentially shock.
EMERGENCY: Seek immediate medical attention or call emergency services if experiencing confusion, severe difficulty breathing, chest pain, or collapse.
Fatigue and Weakness
(constitutional)General feeling of extreme tiredness and reduced energy levels due to hemolytic anemia caused by G6PD deficiency.
Frequency: 70-80% of patients
Pale Skin
(dermatologic)Unusually pale complexion resulting from reduced red blood cell count due to hemolysis.
Frequency: 60-70% of patients
Dark Urine
(gastrointestinal)Urine appears dark yellow, brown, or tea-colored due to the presence of hemoglobin from breaking down red blood cells.
Frequency: 50-60% of patients
Jaundice
(dermatologic)Yellowing of the skin and whites of the eyes due to elevated bilirubin levels from red blood cell breakdown.
Frequency: 40-50% of patients
Rapid Heart Rate
(cardiovascular)Elevated heart rate (tachycardia) as the heart works harder to compensate for reduced oxygen-carrying capacity of blood.
Frequency: 40-50% of patients
Shortness of Breath
(respiratory)Difficulty breathing or feeling out of breath, especially during physical activity, due to decreased oxygen delivery to tissues.
Frequency: 30-40% of patients
Back Pain
(musculoskeletal)Pain in the back region, often in the lower back, caused by hemolysis and increased metabolic activity in the bone marrow.
Frequency: 15-20% of patients
Abdominal Pain
(gastrointestinal)Pain or discomfort in the abdominal area, sometimes related to splenic enlargement or hemolytic episodes.
Frequency: 10-15% of patients
Enlarged Spleen
(constitutional)Splenomegaly due to the spleen working harder to filter out damaged red blood cells during hemolytic episodes.
Frequency: 5-10% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Tissue-level G6PD activity monitoring
Specialized laboratory testing to assess G6PD enzyme activity in affected tissues, guiding treatment intensity and frequency of follow-up assessments.
Systemic oxidative trigger elimination
Comprehensive dietary modifications avoiding fava beans, certain legumes, and foods that increase oxidative burden on tissues with deficient G6PD activity.
Additional treatment options
Hematology-guided pharmaceutical management
Careful medication selection avoiding oxidant-class drugs, with hematology consultation to identify safe alternatives for conditions requiring treatment.
medicationEnvironmental oxidant exposure reduction
Avoidance of chemical oxidants in household products, occupational exposures, and environmental pollutants that could trigger tissue damage in G6PD-deficient cells.
lifestyleTissue biopsy for diagnosis confirmation
When non-invasive testing is inconclusive, targeted tissue biopsy may be performed to confirm G6PD deficiency and guide long-term management strategies.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Glucose 6 Phosphate Dehydrogenase Level In Tissue C4703671?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
World Health Organization. Glucose-6-phosphate dehydrogenase deficiency: WHO Working Group. Bull World Health Organ. 1989;67(6):601-611.
World Health Organization. Guidelines for the treatment of malaria. 3rd edition. Geneva: WHO; 2015.
American Society of Hematology. Clinical practice guidelines: red blood cell disorders. Blood. 2020;135(11):e61-e70.
Luzzatto L, Ally M, Notaro R. Glucose-6-phosphate dehydrogenase deficiency. Blood. 2020;136(11):1225-1240.
Howes RE, Piel FB, Patil AP, et al. G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map. PLoS Med. 2012;9(11):e1001339.
Cappellini MD, Fiorelli G. Glucose-6-phosphate dehydrogenase deficiency. Lancet. 2008;371(9606):64-74.
Baird JK, Hoffman SL. Primaquine therapy for malaria. Clin Infect Dis. 2004;39(9):1336-1345.
Beutler E. G6PD deficiency. Blood. 1994;84(11):3613-3636.
Hoffbrand AV, Pettit JE, Vyas P. Color atlas of clinical hematology. 4th ed. London: Mosby; 2010.
CDC. Glucose-6-phosphate dehydrogenase (G6PD) deficiency. Atlanta: Centers for Disease Control and Prevention; 2022.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy