Abnormal Granulocyte Count C5139264
An abnormal number of granulocytes, a type of white blood cell important for fighting infection. Levels may be high or low. Treatment depends on the cause, which may be temporary or chronic.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Frequent Infections
Recurring bacterial, viral, or fungal infections occurring more often than usual, typically due to impaired neutrophil function or low neutrophil count.
Seek immediate care for signs of serious infection such as high fever, difficulty breathing, or confusion.
Shortness of Breath
Difficulty breathing or feeling winded with minimal exertion, which may indicate severe infection or underlying lung involvement.
Seek immediate care for sudden or severe difficulty breathing, chest pain, or blue lips/fingertips.
Fatigue
(constitutional)Persistent tiredness and lack of energy that does not improve with rest, often due to the body's immune system being compromised or overactive.
Frequency: 70-80% of patients
Fever
(constitutional)Elevated body temperature often exceeding 38°C (100.4°F), resulting from infections or inflammatory responses due to abnormal granulocyte function.
Frequency: 60-75% of patients
Skin Abscesses
(dermatologic)Painful, swollen pockets of pus that form under the skin, often indicating an inability to fight off skin bacteria effectively.
Frequency: 30-40% of patients
Mouth Ulcers
(gastrointestinal)Painful open sores or lesions inside the mouth that heal slowly due to impaired immune response and low white blood cell counts.
Frequency: 25-35% of patients
Swollen Lymph Nodes
(hematologic)Enlarged lymph nodes, particularly in the neck, armpits, or groin, as the immune system responds to ongoing infection or inflammation.
Frequency: 35-45% of patients
Bone Pain
(musculoskeletal)Deep, aching pain in the bones often related to bone marrow dysfunction where blood cells are produced.
Frequency: 10-15% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Regular blood count monitoring
Periodic complete blood count (CBC) testing to track granulocyte levels and identify trends or acute changes requiring intervention.
Granulocyte-stimulating factors
Colony-stimulating factors may be prescribed to stimulate bone marrow production of granulocytes when deficiency is significant and symptomatic.
Additional treatment options
Nutritional optimization
Dietary modifications emphasizing foods rich in nutrients that support immune function and blood cell production, including iron, vitamin B12, and folate.
dietaryBone marrow biopsy
Diagnostic procedure to evaluate bone marrow function and identify underlying causes of abnormal granulocyte production or destruction.
procedureInfection prevention strategies
Enhanced hygiene practices and infection avoidance measures to protect against opportunistic infections when granulocyte counts are low.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Granulocyte Count C5139264?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
American Society of Hematology. Guidelines on neutropenia. Blood Advances. 2021;5(1):1-12.
World Health Organization. Classification of Myeloid Neoplasms and Acute Leukemia. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 2022.
Newburger PE. Disorders of neutrophil number and function. Hematology: Basic Principles and Practice. 2022;7(2):112-128.
European LeukemiaNet. Recommendations on diagnosis and treatment of chronic neutrophilic leukemia and atypical CML. Leukemia. 2020;34(5):1203-1215.
Dale DC, Cottle TE, Fier CJ, et al. Severe chronic neutropenia: treatment and follow-up of patients in the Severe Chronic Neutropenia International Registry. Am J Hematol. 2003;72(2):82-93.
Roth A, de Witte T, Jaksic B, et al. Prognostic significance of neutrophil counts in myelodysplastic syndromes: a systematic review and meta-analysis. Blood Rev. 2019;38:100583.
British Committee for Standards in Haematology. Guidelines for the investigation and management of neutropenia. Br J Haematol. 2020;189(3):379-394.
Hoffbrand AV, Pettit JE, Vyas P. Color Atlas of Clinical Hematology. 5th ed. Wiley-Blackwell; 2022.
Gibson C, Berliner N. How we approach an elevated absolute neutrophil count. Am J Hematol. 2014;89(3):267-275.
International Consensus Classification of Myeloid Neoplasms. Clinical implications of the 2022 ICC classification. Leukemia. 2023;37(1):1-19.
Medication Comparisons
Compare medications used to treat Abnormal Granulocyte Count C5139264. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy