Abnormal Hdl Subfraction Concentration C5139331
Abnormal levels of HDL cholesterol subfractions, which are different types of "good" cholesterol particles in the blood. This finding may reflect metabolic or lifestyle factors. Treatment focuses on overall heart health through diet, exercise, and addressing underlying causes.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Sudden cardiac event
Rare but serious manifestation including heart attack or stroke in advanced cases with significant HDL dysfunction.
EMERGENCY: Seek immediate medical attention for chest pain radiating to arm/jaw, sudden weakness, confusion, or loss of consciousness.
Persistent fatigue
(constitutional)Generalized tiredness and lack of energy that persists despite rest, often related to impaired lipid metabolism.
Frequency: 70-80% of patients
Chest discomfort
(cardiovascular)Mild chest pressure or discomfort, particularly during physical exertion, due to early atherosclerotic changes.
Frequency: 40-50% of patients
Heart palpitations
(cardiovascular)Awareness of irregular or rapid heartbeats, often noticed at rest or during mild activity.
Frequency: 30-40% of patients
Shortness of breath
(respiratory)Difficulty breathing or feeling winded with minimal exertion, related to cardiovascular deconditioning.
Frequency: 35-45% of patients
Xanthelasma
(dermatologic)Yellowish cholesterol deposits on the eyelids or around the eyes, visible skin manifestation of lipid abnormalities.
Frequency: 10-15% of patients
Peripheral tingling
(neurologic)Numbness or tingling sensation in extremities, potentially related to microvascular changes from dyslipidemia.
Frequency: 10-20% of patients
Reduced exercise tolerance
(cardiovascular)Decreased ability to perform physical activities that were previously manageable without fatigue.
Frequency: 45-55% of patients
Right upper quadrant discomfort
(gastrointestinal)Mild discomfort or fullness in the upper right abdomen, potentially related to fatty liver changes.
Frequency: 15-20% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Aerobic exercise program
Regular moderate-intensity exercise such as walking, cycling, or swimming to improve HDL levels and overall cardiovascular health.
Healthy lifestyle changes and stress management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Mediterranean-style diet
Diet rich in olive oil, nuts, fish, fruits, and vegetables to naturally support healthy HDL levels and lipid profiles.
Additional treatment options
Niacin supplementation
Prescription-strength niacin may be considered when lifestyle changes are insufficient, as it can raise HDL levels.
medicationLipid panel monitoring
Regular blood testing to track HDL trends over time and assess effectiveness of interventions.
monitoringSmoking cessation
Complete cessation of tobacco use, which directly damages HDL function and cardiovascular protection.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Hdl Subfraction Concentration C5139331?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC Guideline on the Management of Blood Cholesterol. Circulation. 2019;139:e1082-e1143.
Gordon SM, Davidson WS. Apolipoprotein A-I mimetic peptides and HDL: in vitro and in vivo processing of HDL subpopulations. Curr Opin Lipidol. 2012;23(3):231-237.
Kontush A, Chapman MJ. HDL: close to our metabolic and inflammatory processes? Arch Cardiovasc Dis. 2010;103(3):150-151.
Kim Y, Lee H, Lee S, et al. Association of HDL subfractions with incident cardiovascular disease: a systematic review and meta-analysis. J Clin Lipidol. 2020;14(2):243-255.
International Atherosclerosis Society Panel. Harmonizing HDL research and clinical practice: position statement from the International Atherosclerosis Society. J Clin Lipidol. 2019;13(5):720-731.
Rader DJ, Hovingh GK. Lipoprotein(a) and cardiovascular disease: emerging findings. N Engl J Med. 2014;371(1):75-84.
Mach F, Baigent C, Catapano AL, et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2020;41(1):111-188.
Brown MS, Goldstein JL. A century of cholesterol and coronary heart disease: the legacy of Michael Brown and Joseph Goldstein. Annu Rev Biochem. 2022;91:1-21.
Boden WE, Probstfield JL, Anderson T, et al. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N Engl J Med. 2011;365(24):2255-2267.
Sullivan D, Ross R, McGill H. High-density lipoprotein subclasses and cardiovascular disease. In: Ballantyne CM, ed. Clinical Lipidology: A Companion to Braunwald's Heart Disease. 3rd ed. Elsevier; 2020:89-105.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy