Abnormal Hdl2a Concentration C5139332
Abnormal levels of HDL2a, a specific subtype of "good" cholesterol in the blood. This may reflect changes in how the body processes fats. Lifestyle modifications and medical management aim to improve overall cholesterol balance.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Chest discomfort
Pressure, tightness, or squeezing sensation in the chest that may occur with activity or at rest.
Seek immediate medical attention if chest pain is severe, radiating to arm/jaw, or accompanied by shortness of breath or sweating.
Jaundice
Yellowing of the skin and whites of the eyes, indicating possible liver involvement.
Seek medical care promptly if jaundice appears suddenly or is accompanied by dark urine, pale stools, or severe abdominal pain.
Persistent fatigue
(constitutional)Unexplained tiredness and lack of energy that does not improve with rest.
Frequency: 70-80% of patients
Shortness of breath
(respiratory)Difficulty breathing or feeling winded, especially during physical exertion or when lying flat.
Frequency: 35-45% of patients
Elevated blood pressure
(cardiovascular)Consistently high blood pressure readings, often without noticeable symptoms.
Frequency: 40-55% of patients
Xanthomas
(dermatologic)Yellowish cholesterol deposits in the skin, commonly appearing on tendons, eyelids, or around joints.
Frequency: 10-15% of patients
Abdominal discomfort
(gastrointestinal)General abdominal pain, bloating, or fullness, particularly in the upper abdomen.
Frequency: 30-40% of patients
Reduced exercise tolerance
(constitutional)Inability to perform physical activities that were previously manageable without excessive fatigue.
Frequency: 45-55% of patients
Nausea
(gastrointestinal)Feeling of sickness with an urge to vomit, which may occur intermittently.
Frequency: 15-20% of patients
Weight gain
(metabolic)Unexplained increase in body weight, particularly around the midsection.
Frequency: 35-45% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Omega-3 fatty acid supplementation
Increased intake of omega-3 rich foods such as fatty fish, flaxseed, and walnuts to support healthy HDL2a subfraction levels.
Regular physical activity regimen
Structured exercise program combining aerobic and resistance training to optimize HDL subfraction distribution.
Additional treatment options
Fibrate therapy
Prescription fibrate medications may be considered to modify HDL subfractions when indicated by cardiovascular risk.
medicationAlcohol moderation
Moderate alcohol consumption, particularly red wine, may support healthy HDL levels when appropriate.
lifestyleAdvanced lipid testing
Specialized laboratory evaluation of HDL subfractions to guide personalized treatment strategies.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Hdl2a Concentration C5139332?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC Guideline on the Management of Blood Cholesterol. J Am Coll Cardiol. 2019;73(24):e285-e350.
Mach F, Baigent C, Catapano AL, et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2020;41(1):111-188.
Gordon SM, Davidson WS. Apolipoprotein A-I mimetics and high-density lipoprotein function. Curr Opin Lipidol. 2012;23(3):235-240.
Kontush A, Chapman MJ. Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis. Pharmacol Rev. 2006;58(3):342-374.
Boden WE, Probstfield JL, Anderson T, et al. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N Engl J Med. 2011;365(24):2255-2267.
Liu C, Dhindsa D, Almuwaqqat Z, et al. Association between high-density lipoprotein cholesterol levels and adverse cardiovascular outcomes: a systematic review and meta-analysis. JAMA Cardiol. 2022;7(6):654-663.
American Diabetes Association. 10. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes-2022. Diabetes Care. 2022;45(Suppl 1):S144-S174.
Bishop ML, Fody EP, Schoeff LE. Clinical Chemistry: Techniques, Principles, Correlations. 8th ed. Wolters Kluwer; 2017.
National Lipid Association Expert Panel. Consensus statements from the National Lipid Association on statin safety and associated recommendations. Am J Cardiol. 2014;113(5):703-772.
World Health Organization. Global Health Estimates 2020: Deaths by Cause, Age, Sex, by Country and by Region. Geneva: WHO; 2020.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy