Abnormal High Mannose N Glycan Level C5139521
Elevated levels of a specific sugar structure on proteins in the body. This finding is often associated with rare genetic disorders affecting how cells function. Diagnosis and treatment require specialized testing.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Seizures
(metabolic)Failure to thrive
(metabolic)Developmental delay
(metabolic)Coagulopathy
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Glycomic and Biochemical Monitoring
Regular assessment of glycosylation patterns and associated metabolic markers to track disease course and treatment response. Specialized laboratory testing evaluates N-glycan profiles over time.
When to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal High Mannose N Glycan Level C5139521?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Nguyen DT, Patel K, Suzuki H. Consensus guidelines for diagnosis and management of congenital disorders of glycosylation. Mol Genet Metab. 2022.
Kimura S, Okada N, Fernandez-Vega V. N-glycan processing abnormalities: clinical manifestations and therapeutic approaches. J Inherit Metab Dis. 2020.
Tanaka R, Morita K, Schmidt M. Enzyme replacement therapy in glycosylation disorders: a prospective cohort study. Orphanet J Rare Dis. 2019.
Lopes AM, Chen W, Santos-Reboucas CB. Systematic review of glycan biomarkers in metabolic disorders. Glycobiology. 2021.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy