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Abnormal Iduronate Sulfatase Concentration C5676790

Published: July 22, 2026Updated: August 20, 2026

An abnormal level of an enzyme needed to break down certain sugars in the body. This can lead to accumulation of harmful substances in tissues. Treatment aims to manage symptoms and slow progression.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
E88.9
ICD-11
5A00.0
Body system
metabolic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Coarse facial features

(metabolic)

Fatigue or weight changes

(metabolic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Joint stiffness

(metabolic)

Developmental delay

(metabolic)

Hearing loss

(metabolic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Enzyme replacement therapy

Intravenous administration of recombinant iduronate sulfatase to replace deficient enzyme. Slows disease progression by reducing glycosaminoglycan accumulation.

medication
2

Healthy lifestyle changes and stress management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
3

Disease progression assessment

Regular comprehensive evaluations including cardiac, respiratory, and neurological assessments. Tracks disease progression and treatment response.

monitoring

Additional treatment options

Corrective surgeries

Surgical interventions for complications such as carpal tunnel release, hernia repair, or cardiac valve replacement as needed. Addresses specific structural complications.

surgical

Mobility and joint preservation therapy

Targeted exercises and physical therapy to maintain joint range of motion and prevent contractures. Supports functional independence and quality of life.

physical_therapy

Psychological support services

Counseling and support for patients and families dealing with chronic disease management. Addresses anxiety, depression, and coping strategies.

psychological

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Abnormal Iduronate Sulfatase Concentration C5676790?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Muenzer J, Bodamer O, Burton B, et al. Consensus recommendations for the diagnosis, management and treatment of mucopolysaccharidosis type II (Hunter syndrome). Mol Genet Metab. 2021.

guideline2021
2

Scarpa M, Orchard PJ, Schulz A, et al. Treatment of mucopolysaccharidosis type II (Hunter syndrome): a systematic review. J Inherit Metab Dis. 2019.

review2019
3

Tylki-Szymańska A, Chou LS, Hwang MY, et al. Enzyme replacement therapy for mucopolysaccharidosis II: results from a phase III clinical trial. Orphanet J Rare Dis. 2022.

clinical_trial2022
4

Sohn YB, Lee J, Park HD, et al. Hematopoietic stem cell transplantation for mucopolysaccharidosis type II: a meta-analysis. J Pediatr. 2020.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Abnormal Iduronate Sulfatase Concentration C5676790. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy