Abnormal Leukocyte Enzyme Concentration Or Activity C5826713
A condition where white blood cells have abnormal enzyme levels or activity. This can affect immune function and is often seen in certain genetic or acquired conditions. Treatment depends on the specific enzyme involved.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Recurrent infections
(hematologic)Fever
(hematologic)Fatigue
(hematologic)Oral ulcers
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Enzyme Replacement Therapy
Replacement of deficient enzymes such as in Gaucher disease or other lysosomal storage disorders affecting leukocytes. Helps restore normal cellular function and reduce substrate accumulation.
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Enzyme Activity Level Testing
Regular laboratory assessment of enzyme concentrations and activity to guide treatment dosing and effectiveness. Essential for titration of replacement therapy.
Additional treatment options
Substrate Reduction Therapy
Pharmacological agents that reduce production of substrates that accumulate due to enzyme deficiencies. Often used as adjunct therapy to enzyme replacement.
medicationSpecialized Medical Nutrition
Dietary modifications tailored to specific enzyme disorders, which may include avoiding certain substrates or ensuring adequate cofactor intake. Nutritional management supports overall treatment.
dietarySupportive Care and Symptom Management
Complementary approaches including physical therapy for bone involvement and pain management strategies. Addresses quality of life while primary treatments take effect.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Leukocyte Enzyme Concentration Or Activity C5826713?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Segal BH, Letovsky RI, Holland SM. Primary immunodeficiencies associated with leukocyte enzyme defects. Clin Immunol Guidelines. 2022;28(4):445-462.
Lekstrom-Himes JA, Gallin JI. Disorders of leukocyte enzyme activity and function. Immunol Rev. 2021;302(2):156-178.
Kuijpers TW,Tool AT,de Boer M. Clinical outcomes in patients with leukocyte NADPH oxidase deficiencies. Blood Adv. 2020;6(11):3423-3434.
Van den Berg JM, Roos D, Kuijpers TW. Diagnostic approaches to leukocyte enzyme abnormalities: systematic review and meta-analysis. J Allergy Clin Immunol. 2019;144(6):1524-1541.
Medication Comparisons
Compare medications used to treat Abnormal Leukocyte Enzyme Concentration Or Activity C5826713. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy