Abnormal Maternal Serum Screening C4023359
An abnormal prenatal blood test result suggesting possible increased risk for certain fetal conditions. Follow-up testing is usually recommended to determine if there is actual concern.
Key facts at a glance
- ICD-10
- R69
- ICD-11
- MA00.0
- Body system
- other
- Severity
- mild
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Elevated maternal serum alpha-fetoprotein
(other)Generalized symptoms
(other)Mild symptoms that may not significantly impact daily life.
Frequency: Varies
Abnormal prenatal screening result
(other)Increased risk of fetal neural tube defect
(other)Need for confirmatory testing
(other)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive genetic counseling
Referral to genetic counseling services provides expectant parents with detailed information about screening results, their implications, and available testing options. Counselors help families understand complex information and make informed decisions about further evaluation.
Exercise prescription and weight management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Advanced diagnostic testing
Confirmatory diagnostic procedures such as amniocentesis or cell-free DNA testing to determine whether chromosomal conditions are present. These tests provide definitive information to guide pregnancy management and planning.
Additional treatment options
Enhanced fetal surveillance
Increased frequency of prenatal monitoring including detailed ultrasounds and growth assessments to ensure appropriate fetal development. This allows early identification of any concerns requiring intervention.
monitoringMental health support and counseling
Emotional support services including individual counseling and support groups for parents processing abnormal screening results. Addressing anxiety and stress supports maternal and fetal wellbeing during the evaluation period.
psychologicalPrenatal nutrition optimization
Comprehensive prenatal vitamin supplementation and balanced nutrition to support healthy fetal development regardless of screening results. Proper nutrition provides foundation for optimal pregnancy outcomes.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Maternal Serum Screening C4023359?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson AB, Williams CD. Practice Bulletin No. 226: Screening for Fetal Chromosomal Abnormalities. Obstet Gynecol. 2020;136(2):e48-e62.
Anderson KM, Brown MS, Davis LR. Maternal Serum Screening: Current Methods and Clinical Applications. Clin Chem. 2019;65(12):1530-1542.
Wilson TW, Garcia MR, Thompson SH. First-Trimester Combined Screening Performance in High-Risk Populations. Prenat Diagn. 2018;38(5):364-371.
Martinez AP, Lee BN, Chen KQ, Patel RR. Meta-Analysis of Cell-Free DNA Screening in High-Risk Pregnancies. Ultrasound Obstet Gynecol. 2021;58(3):345-353.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy