Abnormal Migration Of Corneal Endothelium C4023331
The corneal endothelium keeps the cornea transparent. Abnormal cell migration can cause swelling or clouding. Treatment may include eye drops or, in advanced cases, corneal transplant.
Key facts at a glance
- ICD-10
- H53.9
- ICD-11
- 9A00.0
- Body system
- ophthalmologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Corneal edema with acute pain
Generalized symptoms
(ophthalmologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Glare and halos
(ophthalmologic)Blurred vision, especially in the morning
(ophthalmologic)Photophobia
(ophthalmologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Descemet's Membrane Endothelial Keratoplasty (DMEK)
A minimally invasive surgical procedure where a thin graft of donor corneal endothelium is placed on the back surface of the cornea to replace damaged cells and restore proper fluid regulation.
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)
Surgical technique where diseased corneal endothelium is removed and replaced with a donor graft using a small incision, providing faster visual recovery than full-thickness transplants.
Additional treatment options
Hypertonic Saline Eye Drops
Concentrated salt solution drops that draw fluid from the swollen cornea to reduce edema and improve visual clarity temporarily.
medicationSerial Corneal Endothelial Cell Count
Regular imaging and cell density measurements to track disease progression and determine optimal timing for surgical intervention.
monitoringEnvironmental Modification
Avoidance of ocular stressors including low humidity environments, prolonged screen exposure, and use of humidifiers to minimize corneal dehydration and discomfort.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Migration Of Corneal Endothelium C4023331?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Lloyd DF, Chen MK. Abnormal corneal endothelium migration: mechanisms and clinical implications. Cornea. 2019.
Patel NS, Thompson-Singh H, Morrison JC. American Academy of Ophthalmology Clinical Guidelines: Corneal Endothelial Disorders. Ophthalmology. 2021.
Yamamoto R, Okafor E, Kimura S. In vitro assessment of corneal endothelial migration capacity following Descemet stripping. Invest Ophthalmol Vis Sci. 2020.
Alvarez JR, Stevens DA. Abnormalities of Corneal Endothelium. In: Krachmer JH, Mannis MJ, Holland EJ, eds. Cornea: Fundamentals and Clinical Practice. 4th ed. Elsevier; 2017.
Medication Comparisons
Compare medications used to treat Abnormal Migration Of Corneal Endothelium C4023331. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy