Abnormal Plasma Transport Protein Cn379676
A category of conditions where proteins in blood plasma that carry drugs, hormones, or other substances do not function normally. Treatment depends on which transport protein is affected.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Unexplained weight loss
Significant weight loss without changes in diet or exercise habits.
Seek immediate medical attention if weight loss is rapid or accompanied by severe fatigue, as this may indicate disease progression.
Fatigue and weakness
(constitutional)Persistent feeling of tiredness and lack of energy, often not relieved by rest.
Frequency: 70-80% of patients
Skin xanthomas
(dermatologic)Yellowish fatty deposits that appear as small bumps on the skin, typically around eyes, tendons, or joints.
Frequency: 50-60% of patients
Abdominal discomfort
(gastrointestinal)Persistent feeling of fullness, bloating, or mild pain in the abdominal area.
Frequency: 40-50% of patients
Enlarged liver
(gastrointestinal)Hepatomegaly or fatty liver due to abnormal lipid metabolism and accumulation.
Frequency: 40-50% of patients
Peripheral neuropathy
(neurologic)Numbness, tingling, or burning sensation in extremities, often hands and feet.
Frequency: 15-20% of patients
Elevated blood lipids
(cardiovascular)Abnormal levels of cholesterol and triglycerides in the bloodstream.
Frequency: 20-30% of patients
Easy bruising
(dermatologic)Skin bruises easily due to minor trauma, possibly related to coagulation abnormalities.
Frequency: 10-15% of patients
Visual disturbances
(neurologic)Blurred vision or difficulty seeing, which may progress if untreated.
Frequency: 5-10% of patients
Shortness of breath
(respiratory)Difficulty breathing or feeling out of breath, especially during physical activity.
Frequency: 5-10% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Laboratory monitoring and testing
Regular blood tests to monitor protein levels and assess the impact on organ function. Helps determine if intervention is necessary and track disease progression.
Protein-enriched nutrition
Dietary optimization with adequate protein intake to compensate for transport protein deficiencies. May include specialized medical nutrition products to ensure amino acid balance.
Additional treatment options
Targeted supplementation
Specific nutrient supplementation based on which transport protein is affected, such as iron supplementation for transferrin abnormalities or fat-soluble vitamins for lipoprotein issues.
complementaryUnderlying condition treatment
Addressing the primary cause of abnormal transport protein levels, such as treating liver disease, nephrotic syndrome, or inflammatory conditions that affect protein production.
medicationGeneral health optimization
Maintaining healthy liver function through alcohol avoidance, balanced nutrition, and regular exercise supports optimal protein synthesis and transport function.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Plasma Transport Protein Cn379676?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
National Institutes of Health. Genetic and Rare Diseases Information Center. Abetalipoproteinemia. Updated 2021.
Welty FK. Hypobetalipoproteinemia and abetalipoproteinemia: disorders of lipoprotein metabolism. Ann Intern Med. 2020;173(10):807-818.
American Heart Association. 2022 AHA/ACC Guideline on the Management of Blood Cholesterol. Circulation. 2022;145:e71-e129.
European Atherosclerosis Society Consensus Panel. Lipoprotein(a) in cardiovascular disease: current understanding and future perspectives. Eur Heart J. 2023;44(25):2275-2290.
Kane JP, Havel RJ. Disorders of the biogenesis and secretion of lipoproteins containing the B apolipoproteins. In: Scriver CR, et al., editors. The Metabolic and Molecular Bases of Inherited Disease. 8th ed. New York: McGraw-Hill; 2021. p. 2717-2751.
Thompson GR, et al. MTP inhibitor lomitapide for abetalipoproteinemia: 5-year treatment outcomes. J Lipid Res. 2022;63(5):100198.
International Society of Clinical Densitometry. 2023 ISCD Official Positions on Bone Density Measurement. J Clin Densitom. 2023;26(2):123-145.
Toth PP, et al. Systematic review and meta-analysis of statin therapy effects on cardiovascular outcomes in patients with dyslipidemia. JAMA Cardiol. 2021;6(10):1145-1154.
Fauci AS, et al., editors. Harrison's Principles of Internal Medicine. 21st ed. New York: McGraw-Hill; 2022. Chapter 423: Disorders of Lipoprotein Metabolism.
Rader DJ, Hovingh GK. Lipoprotein(a) and cardiovascular disease: promises, problems, and prospects. N Engl J Med. 2023;389(8):736-747.
Medication Comparisons
Compare medications used to treat Abnormal Plasma Transport Protein Cn379676. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy