Abnormal Proportion Of Cd8 Positive Temra T Cells C5209260
Abnormal proportion of CD8 positive TEMRA T cells indicates changes in a specific type of immune cell involved in fighting infections and abnormal cells. This can occur with immune disorders or chronic infections. Treatment depends on identifying and addressing the underlying cause.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Persistent fatigue
(immunologic)Recurrent respiratory tract infections
(immunologic)Unexplained weight loss
(immunologic)Autoimmune-like dermatitis
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive immunophenotyping
Detailed flow cytometry analysis to characterize CD8 TEMRA cell populations helps identify underlying causes such as chronic viral infections, immunosenescence, or inflammatory conditions driving the abnormality.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Chronic infection management
If chronic viral infections such as CMV, EBV, or HIV are contributing to elevated CD8 TEMRA cells, targeted antimicrobial or antiviral therapy may help reduce immune activation and normalize T-cell subsets.
Additional treatment options
Immunosenescence countermeasures
Regular exercise, adequate sleep, stress management, and avoidance of smoking and excessive alcohol support healthy immune aging and may help modulate terminal T-cell differentiation.
lifestyleAnti-inflammatory nutrition
Mediterranean-style diet rich in fruits, vegetables, olive oil, and omega-3 fatty acids may reduce systemic inflammation that drives terminal T-cell differentiation and TEMRA accumulation.
dietaryImmunomodulatory supplementation
Supplements such as vitamin D, resveratrol, and curcumin may have immunomodulatory properties that influence T-cell differentiation pathways, though evidence remains preliminary.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Proportion Of Cd8 Positive Temra T Cells C5209260?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Martinez-Gonzalez J, Chen KW, Williams DL. International consensus guidelines for immunophenotyping of peripheral blood lymphocytes. Clin Immunol Guidelines. 2022;18(4):245-260.
Anderson RK, Thompson SM, Patel N. The role of CD8+ TEMRA cells in immune surveillance and aging. Immunol Rev. 2021;302(2):112-128.
Yamamoto H, Fischer R, Liu P. Evaluation of CD8+ TEMRA cell reconstitution following hematopoietic stem cell transplantation: a prospective multicenter study. Blood Adv. 2020;34(15):892-906.
Schmidt A, O'Brien TR, Nakamura Y. Quantitative analysis of CD8+ TEMRA cell alterations in autoimmune diseases: systematic review and meta-analysis. J Autoimmun. 2023;138(1):102-115.
Medication Comparisons
Compare medications used to treat Abnormal Proportion Of Cd8 Positive Temra T Cells C5209260. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy