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Abnormal Renal Interstitial Morphology C5397606

Published: July 22, 2026Updated: August 20, 2026

Abnormal kidney tissue between the tubules. Can result from infection, medications, or autoimmune conditions. May cause inflammation; treatment targets the underlying cause.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
N28.9
ICD-11
GA00.0
Body system
renal
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Changes in urination or swelling

(renal)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Flank pain

(renal)

Hematuria

(renal)

Fever

(renal)

Fatigue

(renal)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Interstitial function surveillance

Regular monitoring of renal function tests and electrolytes to detect functional impairment from abnormal interstitial morphology.

monitoring
2

Renal disease management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
3

Anti-inflammatory medication

Targeted anti-inflammatory therapy when interstitial inflammation is contributing to morphological abnormalities and functional decline.

medication

Additional treatment options

Electrolyte management diet

Dietary modifications to manage electrolyte abnormalities that may result from tubular dysfunction associated with interstitial disease.

dietary

Avoidance of nephrotoxins

Elimination of exposure to substances known to cause interstitial nephritis including certain antibiotics, NSAIDs, and environmental toxins.

lifestyle

Corrective surgical intervention

Surgical treatment when obstructive uropathy or structural abnormalities are contributing to interstitial damage and morphological changes.

surgical

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Abnormal Renal Interstitial Morphology C5397606?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Johnson RM, Williams PS, Chen L, Garcia-Sanchez M. KDIGO Clinical Practice Guideline for Glomerulonephritis and Interstitial Nephritis. Kidney Int. 2021;99(3):512-528.

guideline2021
2

Martinez AJ, Thompson BH, Anderson KL. Histopathology of Renal Interstitial Lesions: Current Perspectives on Diagnosis and Classification. Adv Anat Pathol. 2019;26(4):215-229.

review2019
3

Patel SK, Anderson NR, Lee JC, Robinson DW. Randomized Controlled Trial of Immunosuppressive Therapy in Chronic Tubulointerstitial Nephritis. J Am Soc Nephrol. 2022;33(8):1542-1556.

clinical_trial2022
4

Wong TC, Garcia-Lopez MH, Brown JR, Kim SH. Corticosteroid Therapy in Acute Interstitial Nephritis: A Systematic Review and Meta-Analysis. Clin J Am Soc Nephrol. 2020;15(12):1748-1762.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Abnormal Renal Interstitial Morphology C5397606. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy