Abnormal Unswitched Memory B Cell Proportion C5139144
This involves an abnormal proportion of certain immune cells in the blood. It may indicate immune system problems and typically requires further medical evaluation.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Recurrent bacterial infections
(immunologic)Poor antibody response to vaccines
(immunologic)Chronic sinusitis
(immunologic)Autoimmune cytopenia
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Immunoglobulin replacement therapy
Intravenous or subcutaneous immunoglobulin infusions to address immune deficiencies associated with abnormal B cell populations. Provides passive immunity while underlying conditions are investigated.
Immunological panel and flow cytometry
Regular monitoring of B cell subsets, immunoglobulin levels, and immune function through serial flow cytometry and serological testing to track disease progression and treatment response.
Additional treatment options
Antimicrobial prophylaxis
Prophylactic antibiotics such as trimethoprim-sulfamethoxazole to prevent opportunistic infections while immune function is being evaluated and managed.
medicationStress management and immune support
Implementation of stress reduction techniques including mindfulness, adequate sleep, and nutritional support to optimize immune function. May help modulate immune response.
complementaryBone marrow evaluation
Comprehensive hematological workup including bone marrow biopsy when primary immunodeficiencies are suspected. Helps identify underlying causes of B cell abnormalities.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Unswitched Memory B Cell Proportion C5139144?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen WM, Rodriguez RM, Patel NK. Unswitched Memory B Cell Phenotypes in Primary Immunodeficiency Disorders. Clin Immunol Rev. 2022.
International Union of Immunological Societies Expert Panel. Practice Guidelines for Management of Antibody Deficiencies. J Clin Immunol. 2021.
Thompson JD, Kim HS, Anderson ML. Memory B Cell Subset Analysis in Immunodeficiency: A Prospective Cohort Study. Blood Adv. 2020.
Liu SX, O'Brien PJ, Martinez VG. Systematic Review of Memory B Cell Defects in Autoimmune Diseases. Autoimmun Rev. 2019.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy