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Abnormal Urinary 1 Methylhistidine Concentration C5139475

Published: July 22, 2026Updated: August 26, 2026

An abnormal level of 1-methylhistidine in urine, which can reflect muscle metabolism or dietary factors. Further testing helps determine the cause.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 26, 2026Editorial policy

Key facts at a glance

ICD-10
E88.9
ICD-11
5A00.0
Body system
metabolic
Severity
mild
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Fatigue

(metabolic)

Fatigue or weight changes

(metabolic)

Mild symptoms that may not significantly impact daily life.

Frequency: Common at all stages

Increased urination

(urinary)

Muscle weakness

(musculoskeletal)

Mild dehydration

(metabolic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Behavioral and nutritional therapy

Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.

lifestyle
2

Metabolic panel and amino acid profiling

Comprehensive laboratory evaluation including plasma and urine amino acid analysis to characterize the pattern and severity of 1-methylhistidine abnormalities.

monitoring

Additional treatment options

Modified protein intake

Dietary adjustments to reduce intake of precursors that contribute to elevated 1-methylhistidine, including modified portions of meat and poultry.

dietary

Metabolic support supplements

Supplementation with cofactors and nutrients that support normal amino acid metabolism, potentially including B-vitamins and carnitine.

medication

Specialized amino acid challenge testing

Controlled dietary challenge with amino acid measurement to assess metabolic pathway function and determine underlying etiology.

procedure

Nutritional counseling and compliance support

Ongoing support from dietitians to help patients maintain dietary modifications and understand the rationale for treatment.

psychological

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Abnormal Urinary 1 Methylhistidine Concentration C5139475?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Medication Comparisons

Compare medications used to treat Abnormal Urinary 1 Methylhistidine Concentration C5139475. See side-by-side comparisons of effectiveness, side effects, costs, and more.

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy