Abnormal Urine Isobutyrylglycine Concentration C5139640
Isobutyrylglycine is an organic compound that may be found in abnormal concentrations in urine. It can be associated with metabolic conditions. Further evaluation determines if treatment is needed.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Mild symptoms that may not significantly impact daily life.
Frequency: Varies
Growth delay
(metabolic)Anemia
(metabolic)Palpitations
(metabolic)Exercise intolerance
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Low-protein diet modification
Restriction of protein intake to reduce the metabolic burden on pathways that produce isobutyrylglycine. A registered dietitian should design individualized meal plans that meet nutritional requirements while limiting precursor amino acids.
L-carnitine supplementation
Carnitine supplementation supports mitochondrial function and helps conjugate accumulated acyl groups. This therapy aids in normalizing organic acid metabolism and reducing toxic intermediate accumulation.
Additional treatment options
Metabolic laboratory monitoring
Regular monitoring of urine organic acids, plasma amino acids, and acylcarnitine profiles to assess treatment efficacy and disease progression. Serial measurements help guide therapeutic adjustments.
monitoringStress management and illness planning
Implementation of stress reduction techniques and written action plans for acute illness episodes. During metabolic stress, patients may need intensified monitoring and temporary dietary modifications.
lifestyleGenetic counseling
Family genetic counseling provides information about inheritance patterns, recurrence risks, and carrier testing options. This helps families make informed reproductive and family planning decisions.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Urine Isobutyrylglycine Concentration C5139640?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy