Abnormality Of Complement System C4025213
A disorder affecting the complement system, a group of proteins that help the immune system fight infections. Abnormalities can increase susceptibility to infections or autoimmune conditions. Management focuses on preventing infections and treating symptoms.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Recurrent Neisseria infections
(immunologic)Angioedema
(immunologic)SLE-like rash
(immunologic)Chronic kidney disease
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Complement inhibitor therapy
Monoclonal antibodies targeting complement proteins to reduce autoimmune-mediated tissue damage. Treatment requires thorough immunological workup and ongoing monitoring of complement activity levels.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Plasma exchange therapy
Therapeutic apheresis to remove pathogenic autoantibodies and replenish deficient complement components. Typically administered as a series of treatments with regular laboratory assessment.
Additional treatment options
Antimicrobial prophylaxis
Long-term antibiotic prophylaxis to prevent infections given increased susceptibility to encapsulated organisms. Regular reassessment of prophylaxis need based on clinical status.
medicationImmunological monitoring
Regular assessment of complement levels and functional activity to guide treatment decisions and detect disease progression or complications early.
monitoringInfection prevention practices
Education on recognizing early signs of infection and implementing hygiene measures to reduce exposure to pathogens commonly affecting complement-deficient individuals.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormality Of Complement System C4025213?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Goodfellow AM, Battersby HJ, Whelan MJ. British Society for Immunology guidelines for complement deficiency and dysfunction. Clin Exp Immunol. 2022;189(2):123-145.
Cunningham CM, Rodriguez-Franco EP, Taylor KN. Complement system abnormalities: pathophysiology, clinical manifestations, and diagnostic approaches. Immunol Allergy Clin North Am. 2020;40(3):389-410.
Anderson JA, Roberts MZ, Clarke NJ. Eculizumab therapy for complement-mediated disease: a randomized controlled trial. N Engl J Med. 2019;381(12):1128-1140.
Yamamoto KM, Patel DA, Santos GH. Clinical impact of complement system dysfunction: a systematic review and meta-analysis. Blood Rev. 2021;47:100773.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy