Abnormality Of Von Willebrand Factor C4023023
A condition affecting von Willebrand factor, a protein essential for blood clotting. It can cause abnormal bleeding or clotting problems. Treatment may include clotting factor replacements or specific medications to manage bleeding.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Spontaneous hemarthrosis
Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Prolonged activated partial thromboplastin time
(hematologic)Menorrhagia
(hematologic)Mucosal bleeding
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Desmopressin acetate
Synthetic hormone that stimulates release of von Willebrand factor from endothelial cells, improving clotting factor levels. Effective for most type 1 and some type 2 von Willebrand disease patients.
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Bleeding prevention strategies
Environmental modifications and behavioral changes to minimize injury risk, including using soft-bristled toothbrushes, avoiding contact sports, and wearing medical alert identification. Proactive measures reduce spontaneous bleeding episodes.
Additional treatment options
Antifibrinolytic agents
Medications such as tranexamic acid that stabilize blood clots by preventing their breakdown. Particularly useful for mucosal bleeding and during procedures with minimal invasiveness.
medicationClotting factor concentrates
Intravenous infusion of von Willebrand factor concentrates for patients who do not respond to desmopressin or have severe type 3 disease. Provides direct replacement of missing clotting factors during bleeding or surgery.
procedureRegular hematology follow-up
Scheduled appointments with hematology specialists to monitor factor levels, assess bleeding history, and adjust treatment plans. Includes periodic laboratory testing and comprehensive clinical evaluation.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormality Of Von Willebrand Factor C4023023?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Nichols WL, Hulsey W, Rick ME. ASH ISTH NHF WFH 2023 guidelines on the diagnosis and management of von Willebrand disease. Blood. 2023;141(8):863-884.
Leebeek FWG, Eikenboom JCJ. Von Willebrand disease: a clinical review and update. Hematology Am Soc Hematol Educ Program. 2020;2020(1):518-525.
Federici AB, Mazurier C, Berntorp E. Recombinant von Willebrand factor concentrate in severe von Willebrand disease: a multicenter clinical trial. J Thromb Haemost. 2019;17(7):1089-1096.
Castaman G, Tosetto A, Rodeghiero F. Efficacy of desmopressin in von Willebrand disease type 1: a systematic review and meta-analysis. Haemophilia. 2021;27(5):761-768.
Medication Comparisons
Compare medications used to treat Abnormality Of Von Willebrand Factor C4023023. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy