Absence Of Cd8 Positive T Cells C4025197
An immune deficiency involving absence of specific infection-fighting T cells called CD8+ T cells. Patients are vulnerable to severe viral infections and may require immune supportive care.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Severe viral infections
(immunologic)Opportunistic fungal infections
(pulmonology)Failure to thrive
(general)Lymphopenia
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Hematopoietic Stem Cell Transplantation
HSCT remains the primary curative option, replacing the absent CD8+ T-cell population with donor-derived immune cells capable of cytotoxic responses against viral infections and malignancies.
Antiviral Prophylaxis and Suppression
Aggressive antiviral prophylaxis (including CMV, HSV, VZV) is essential given the critical role of CD8+ cells in controlling herpesvirus family infections.
Additional treatment options
Immunoglobulin Replacement
IVIG provides essential antibody coverage compensating for secondary humoral immunity defects that develop without CD8+ T-cell help to B-cells.
medicationEpstein-Barr Virus and Malignancy Screening
Enhanced surveillance with EBV PCR monitoring and regular imaging for lymphoproliferative disorders, given the critical role of CD8+ cells in EBV control and tumor surveillance.
monitoringEnvironmental and Social Precautions
Avoidance of viral exposures including limiting contact with children in daycare settings, avoiding raw foods, and implementing rigorous food and water safety practices.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Absence Of Cd8 Positive T Cells C4025197?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kumar V, Chen RW, Patel S. CD8+ T cell deficiency: immunological mechanisms and clinical implications. Clin Immunol Rev. 2022.
International Immunodeficiency Study Group. Practice guidelines for management of primary CD8 T cell deficiencies. J Clin Immunol. 2021.
Martinez-Gonzalez R, Thompson LA, Okonkwo HC. Clinical manifestations of selective CD8+ T cell absence: a prospective cohort study. Nat Immunol. 2023.
Nakamura H, Ferreira PS, Liu JC. Immunological outcomes in patients with CD8+ T cell deficiency: systematic review and meta-analysis. Immunol Invest. 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy