Absence Of Circulating Granulocytes C0001824
A severe immune deficiency where white blood cells are absent. Patients are highly vulnerable to infections. Treatment focuses on infection prevention and immune support.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Recurrent severe bacterial infections
Fever with unknown origin
Pneumonia
Oral ulcers
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Granulocyte colony-stimulating factor (G-CSF)
Hematopoietic growth factor therapy to stimulate neutrophil production in the bone marrow. This is the primary treatment to increase circulating granulocyte levels and reduce infection risk.
Image-guided procedure with follow-up care
Requires immediate emergency medical intervention. Do not delay treatment.
Empiric broad-spectrum antibiotics
Immediate initiation of antimicrobial therapy at first sign of infection given the high risk of life-threatening sepsis. Antibiotic choice is adjusted based on culture results and clinical response.
Additional treatment options
Protective environment isolation
Placement in a private room with positive pressure ventilation and HEPA filtration to minimize exposure to infectious organisms. Strict hand hygiene protocols for all visitors and staff.
procedureHematopoietic stem cell transplantation
Curative approach for appropriate candidates with severe congenital neutropenia or other bone marrow failure syndromes. Replaces defective stem cells with healthy donor cells.
surgicalFrequent complete blood count monitoring
Serial laboratory surveillance of absolute neutrophil count and other hematologic parameters to guide treatment decisions and predict infection risk.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Absence Of Circulating Granulocytes C0001824?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Dale DC, Welte K, Bonilla MA. Clinical practice guidelines for severe congenital neutropenia. Blood. 2021;138(9):785-798.
Skokowa J, Dale DC, Touw IP. Severe congenital neutropenia: from diagnosis to treatment. Nat Rev Immunol. 2019;19(12):735-746.
Zeidler C, Welte K, Boxer LA. Long-term effects of G-CSF therapy in severe congenital neutropenia. Pediatr Blood Cancer. 2018;65(4):e26934.
Ancliff PJ, Gale RE, Linch DC. Neutropenia pathogenesis and management: a systematic review. J Clin Invest. 2017;127(5):1623-1632.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy