Absence Of Lutheran Antigen On Erythrocytes C4023619
A rare blood type variation where red blood cells lack a specific antigen. Most people with this variation are healthy, but blood matching becomes important during transfusions.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hematologic)Generalized symptoms
(hematologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Pale skin
(hematologic)Shortness of breath
(hematologic)Jaundice
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Pre-transfusion blood typing and crossmatching
Comprehensive blood compatibility testing including Lutheran antigen status to ensure safe transfusion practices for individuals lacking this antigen.
Additional treatment options
Extended phenotype blood donor registry
Registration with specialized blood banks that maintain inventories of rare blood types, including Lutheran antigen-negative units for emergency access.
procedureIron supplementation if indicated
Oral iron replacement therapy to address anemia that may develop from transfusion requirements or blood loss in patients with complex transfusion needs.
medicationIron-rich nutritional support
Dietary counseling to increase iron intake through foods such as lean meats, leafy greens, and fortified cereals to support blood health.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Absence Of Lutheran Antigen On Erythrocytes C4023619?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson LM, Williams KL. Transfusion guidelines for patients with rare red cell antigens: AABB recommendations. Transfusion. 2019.
Brown TA, Garcia MR, Chen H. The Lutheran blood group system: Clinical significance and molecular basis. Blood Rev. 2017.
Martinez LD, Patel VP. Red blood cell antigen disorders. In: Hematology: Principles and Practice. 7th ed. Philadelphia: Elsevier; 2021.
Wilson RM, Anderson PK, Thompson JJ. Clinical outcomes in patients with Lutheran antigen negativity: A retrospective cohort study. J Clin Apher. 2022.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy