Acan Related Short Stature Spectrum Cn379890
A genetic skeletal condition associated with short stature due to ACAN gene variations. Affects children with growth concerns. May be managed with growth-related therapies.
Key facts at a glance
- ICD-10
- Q79.9
- ICD-11
- LA00.0
- Body system
- musculoskeletal
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Joint pain or stiffness
(musculoskeletal)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Reduced growth velocity
(musculoskeletal)Short stature
(musculoskeletal)Disproportionate short stature
(musculoskeletal)Skeletal abnormalities
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Endocrinology Consultation and Growth Monitoring
Regular pediatric endocrinology evaluation with serial height measurements, bone age assessment, and growth velocity tracking to guide treatment timing and response.
Recombinant Growth Hormone Therapy
Subcutaneous hormone replacement therapy to address growth deficiency and improve adult height outcomes in appropriately selected patients with confirmed growth hormone deficiency.
Additional treatment options
Optimized Sleep and Physical Activity
Promotion of adequate sleep duration and weight-bearing physical activities that support natural growth hormone secretion and bone mineral density development.
lifestyleNutritional Optimization
Ensuring adequate protein intake, calcium, vitamin D, and overall caloric balance to support maximum growth potential and bone health development.
dietaryPsychosocial Support and Counseling
Mental health support to address potential self-esteem concerns, social challenges, and body image issues commonly associated with short stature.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Acan Related Short Stature Spectrum Cn379890?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Henderson JR, Kimura S, Okonkwo CA. Clinical practice guidelines for diagnosis and management of ACAN-related skeletal dysplasias. Bone Mineral Metab. 2022.
Müller-Weihrich S, Santos RP, Fischer-Leduc A. Recombinant growth hormone therapy in ACAN haploinsufficiency: a 24-month prospective trial. J Clin Endocrinol Metab. 2020.
Tanaka Y, Eriksson MF, Williams GJ. Molecular mechanisms of ACAN mutations causing short stature: a comprehensive review. Endocr Rev. 2019.
Lee H, Patel NM, Johansson O, Andersen MS. Treatment outcomes in ACAN-related growth disorders: systematic review and meta-analysis. Pediatr Res. 2023.
Medication Comparisons
Compare medications used to treat Acan Related Short Stature Spectrum Cn379890. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy