Acanthamoeba Infectious Disease Cn281874
A parasitic infection caused by Acanthamoeba organisms found in water and soil that can affect the eyes, skin, or internal organs. People with weakened immune systems are most at risk. Treatment requires aggressive antimicrobial therapy and can be difficult.
Key facts at a glance
- ICD-10
- B99.8
- ICD-11
- 1A00.0
- Body system
- infectious
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Vision loss
Severe headache
Fever or malaise
(infectious)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Acanthamoeba keratitis (corneal ulcer)
(infectious)Cutaneous nodules
(infectious)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antimicrobial or antiviral therapy
Active treatment with regular monitoring by a healthcare provider is recommended.
Systemic Antiprotozoal Therapy
Combination therapy using medications such as pentamidine, azithromycin, or amphotericin B to target the Acanthamoeba organism. Treatment typically requires prolonged duration due to the resistant nature of the parasite.
Combination Antimicrobial Regimen
Use of multiple antimicrobial agents including fluconazole and sulfadiazine to provide broad coverage against the parasitic infection. Often used in conjunction with other antiprotozoal medications.
Additional treatment options
CSF Drainage Procedures
Therapeutic lumbar punctures or shunt placement to manage increased intracranial pressure and remove infectious fluid from the central nervous system.
procedureNeuroimaging and Clinical Surveillance
Regular MRI or CT imaging combined with clinical neurological assessments to monitor disease progression and treatment response over time.
monitoringSupportive Care and Symptom Management
Comprehensive supportive care including pain management, nutritional support, and physical therapy to maintain quality of life during prolonged treatment.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acanthamoeba Infectious Disease Cn281874?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Lorenzo-Morales J, Khan NA, Walochnik J. An update on Acanthamoeba keratitis: diagnosis and treatment. Curr Infect Dis Rep. 2022.
Siddiqui R, Khan NA. Acanthamoeba is an opportunistic pathogen capable of causing infectious disease in immunocompromised hosts. Parasitology. 2019.
Carnt N, Robaei D, Minassian DC, Dart JK. Acanthamoeba keratitis in 465 patients: risk factors and therapeutic outcomes. Ophthalmology. 2018.
Hadaschik E, Ritter M, Hofmann H. Treatment outcomes in Acanthamoeba keratitis: a systematic review and meta-analysis. Eye. 2020.
Medication Comparisons
Compare medications used to treat Acanthamoeba Infectious Disease Cn281874. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy