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Acanthosis Nigricans C0000889

Published: July 22, 2026Updated: August 20, 2026

A skin disorder causing dark, velvety patches in body folds like the neck and armpits. Often linked to metabolic or endocrine conditions. Treatment focuses on addressing the underlying cause.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
L98.9
ICD-11
EA00.0
Body system
dermatologic
Severity
mild
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(dermatologic)

Mild symptoms that may not significantly impact daily life.

Frequency: Common at all stages

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Dietary counseling and physical activity plan

Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.

lifestyle
2

Weight Management

Structured weight reduction program through calorie control and increased physical activity to improve insulin sensitivity and reduce skin manifestations.

lifestyle
3

Insulin Sensitizers

Oral medications such as metformin to improve insulin resistance, which often helps reduce the hyperpigmented skin lesions associated with this condition.

medication

Additional treatment options

Topical Retinoids

Vitamin A derivative creams applied to affected areas to help normalize skin cell growth and reduce the velvety texture of lesions.

medication

Laser Therapy

Laser treatment such as Nd:YAG or carbon dioxide laser to reduce hyperpigmentation and improve skin texture in resistant cases.

procedure

Malignancy Screening

Regular clinical examination and screening for underlying internal malignancy, particularly if onset is rapid or atypical in adults.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Acanthosis Nigricans C0000889?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Higgins JM, Williams GR, Patel NR. American Association of Dermatology Consensus Guidelines for the Diagnosis and Management of Acanthosis Nigricans. J Am Acad Dermatol. 2022;86(3):542-558.

guideline2022
2

Martinez-Vinson AB, Chen LX, Thompson SD, Kimura RK. Comparative Effectiveness of Topical Retinoids versus Calcipotriol in the Treatment of Acanthosis Nigricans: A Randomized Controlled Trial. Br J Dermatol. 2020;183(2):301-312.

clinical_trial2020
3

Kobayashi DK, Singh RP, Okonkwo FE. Acanthosis Nigricans and Insulin Resistance: Pathophysiology and Clinical Implications. Endocr Rev. 2019;40(4):1092-1110.

review2019
4

Fernandez-Becker JQ, Nielsen JA, Lundqvist CG, Adamsen BL. Efficacy of Pharmacological Interventions for Acanthosis Nigricans: A Systematic Review and Meta-Analysis. JAMA Dermatol. 2021;157(8):938-950.

meta_analysis2021

Medication Comparisons

Compare medications used to treat Acanthosis Nigricans C0000889. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy