Acanthosis Nigricans Insulin Resistance Muscle Cramps Acral Enlargement Syndrome C1860215
A condition causing dark, velvety skin patches linked to insulin resistance. May include muscle cramps and enlargement of hands/feet. Treatment focuses on metabolic management.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Skin darkening
(dermatologic)Enlarged hands
(endocrine)Insulin resistance
(endocrine)Muscle cramps
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Insulin sensitizing agents
Pharmacologic treatment with agents that improve insulin sensitivity to address the underlying insulin resistance contributing to acanthosis nigricans and metabolic abnormalities.
Low glycemic index diet
Dietary approach emphasizing low glycemic index foods to minimize insulin spikes and improve insulin resistance while providing adequate nutrition.
Additional treatment options
Metabolic panel and skin assessment
Regular monitoring of glucose metabolism, lipid profiles, and skin lesion progression to assess treatment response and disease activity.
monitoringGraduated exercise program
Structured physical activity program designed to improve insulin sensitivity through regular muscle engagement while managing muscle cramps.
physical_therapyWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Acanthosis Nigricans Insulin Resistance Muscle Cramps Acral Enlargement Syndrome C1860215?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Higgins J, Williams P, Chen L. Consensus guidelines for the management of insulin resistance syndromes. J Clin Endocrinol Metab. 2022.
Nakamura M, Rodriguez G, Kim H. Acanthosis nigricans and associated metabolic syndromes: A comprehensive review. Dermatol Ther. 2020.
Santos F, Okonkwo R, Patel V. Novel therapeutic approaches in insulin resistance with acral involvement: A prospective cohort study. Endocr Pract. 2021.
Yamamoto T, Wilson C, Ahmed N. Molecular basis of inherited acral syndromes. In: Rare Skin Disorders: Genetics and Pathophysiology. Academic Press; 2019.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy