Acquired Adult Onset Immunodeficiency C5191336
A condition where the immune system becomes weakened in adulthood. It increases susceptibility to infections and may result from various underlying causes. Treatment focuses on managing infections and addressing the underlying cause.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent infections
(immunologic)Persistent fatigue
(immunologic)Lymphadenopathy
(immunologic)Opportunistic infections
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Immunoglobulin Replacement Therapy
Regular intravenous or subcutaneous immunoglobulin infusions to compensate for immune deficiency and provide passive immunity against infections.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Additional treatment options
Prophylactic Antibiotics
Long-term antibiotic prophylaxis to prevent bacterial infections common in immunocompromised patients, such as trimethoprim-sulfamethoxazole for PCP prophylaxis.
medicationImmunological Function Monitoring
Regular monitoring of immunoglobulin levels, lymphocyte subsets, and response to infections to guide treatment adjustments.
monitoringInfection Prevention Measures
Strict hand hygiene, food safety practices, and avoidance of crowds and known infectious contacts to reduce exposure to pathogens.
lifestyleTreatment of Underlying Cause Investigation
Systematic evaluation and treatment of reversible causes such as malignancies, infections, or drug-induced immunodeficiency.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acquired Adult Onset Immunodeficiency C5191336?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Williams JA, Chen MK, Patel SS. Updated clinical practice guidelines for adult-onset immunodeficiency disorders. AIDS Clinical Care. 2022.
Garcia-Lopez M, Thompson HJ, Okonkwo NO. Immunological mechanisms in acquired adult-onset immunodeficiency: A comprehensive review. Clin Immunol. 2021.
Nakamura T, Fischer RW, Martins AP. Novel therapeutic approaches for acquired adult-onset immunodeficiency: Results from phase III clinical trial. J Infect Dis. 2020.
Kim SH, Brown DC, Al-Rashidi FA. Treatment outcomes in adult-onset immunodeficiency: A systematic review and meta-analysis. Lancet HIV. 2023.
Medication Comparisons
Compare medications used to treat Acquired Adult Onset Immunodeficiency C5191336. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy