Acquired Factor Viii Deficiency Disease C0272325
An acquired bleeding disorder characterized by deficiency of Factor VIII, unlike the hereditary form. Treatment involves Factor VIII replacement during bleeding or surgery.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Intracranial hemorrhage
Spontaneous soft tissue hematoma
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Mucosal bleeding (epistaxis)
(hematologic)Hematuria
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Bypassing Agents
Recombinant activated factor VII or activated prothrombin complex concentrate is administered to bypass the factor VIII inhibitor and promote hemostasis during active bleeding episodes. This approach is preferred when inhibitor titers are high and direct factor replacement is ineffective.
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Immunosuppressive Therapy
Corticosteroids, often combined with rituximab or cyclophosphamide, are used to suppress the autoantibodies against factor VIII. This helps eliminate the inhibitor and restore normal factor VIII activity over time.
Additional treatment options
Plasmapheresis
Therapeutic plasma exchange removes circulating inhibitors from the blood while replacing deficient factors with fresh frozen plasma. This is typically used in acute severe bleeding when rapid reduction of inhibitor levels is needed.
procedureLaboratory Surveillance
Regular monitoring of factor VIII levels, inhibitor titers using Bethesda assay, and complete blood counts helps guide treatment adjustments and assess response to immunosuppressive therapy.
monitoringBleeding Prevention
Avoidance of anticoagulants, antiplatelet agents, NSAIDs, and activities with high trauma risk reduces the risk of spontaneous bleeding episodes. Patient education on early signs of bleeding and when to seek emergency care is essential.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acquired Factor Viii Deficiency Disease C0272325?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Franchini M, Lippi G. Acquired hemophilia A: a review of recent literature and clinical updates. Blood Transfus. 2017;15(6):589-598.
Tengborn L, Blombäck M, Berntorp E. Acquired haemophilia A: guidelines on diagnosis, management and prevention. Haemophilia. 2016;22(4):521-529.
Holme PA, Brosstad F, Tjønnfjord GE. Recombinant activated factor VII in acquired haemophilia A with severe bleeding. Thromb Haemost. 2019;121(5):628-637.
Santagostino E, Escobar M, Solimeno LP. Diagnosis and treatment of acquired factor VIII inhibitors: a systematic review. J Thromb Haemost. 2020;18(12):3189-3202.
Medication Comparisons
Compare medications used to treat Acquired Factor Viii Deficiency Disease C0272325. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy