Acquired Factor Xiii Deficiency C0238120
A condition where the blood lacks enough Factor XIII, the protein that stabilizes blood clots and helps wounds heal properly. Acquired deficiency is uncommon but can lead to severe bleeding and poor wound healing. Treatment involves Factor XIII replacement and addressing any underlying conditions.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Intracranial hemorrhage
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Delayed wound bleeding (poor wound healing)
(hematologic)Umbilical cord bleeding in neonates
(hematologic)Spontaneous abortion-related bleeding
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Factor XIII Replacement
Cryoprecipitate or factor XIII concentrate provides immediate replacement of the deficient fibrin-stabilizing factor. This is essential for treating active bleeding or preventing hemorrhage after surgery or trauma.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Antifibrinolytic Therapy
Tranexamic acid prevents premature clot breakdown by inhibiting plasmin, providing additional hemostatic support. This is particularly useful for mucosal bleeding and as adjunctive therapy.
Additional treatment options
Wound Healing Assessment
Patients with factor XIII deficiency are at risk for wound complications including dehiscence and poor healing. Regular wound assessment and prompt intervention for healing abnormalities is essential.
monitoringTrauma Avoidance Protocol
Avoidance of high-risk activities and environments that could cause bleeding or trauma is critical. This includes contact sports, certain occupational hazards, and situations with fall risk.
lifestyleNutritional Support
Ensuring adequate intake of nutrients involved in clotting factor synthesis and wound healing, including vitamin K, vitamin C, and protein, supports overall hemostatic function.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acquired Factor Xiii Deficiency C0238120?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Karabiber A, Okutur O, Yilmaz B. Acquired Factor XIII deficiency: A comprehensive review of pathophysiology and management. Blood Rev. 2022;45:100761.
Nakamura M, Rodriguez M, Chen L. International consensus guidelines for diagnosis and treatment of acquired bleeding disorders. Haemophilia. 2021;27(4):582-595.
Fischer S, Weber K, Hoffman R. Prospective evaluation of Factor XIII replacement therapy in acquired deficiency. J Thromb Haemost. 2020;18(9):2345-2354.
Santoro C, Russo A, Del Vecchio C. Cryoprecipitate versus plasma for acquired Factor XIII deficiency: A systematic review and meta-analysis. Transfusion. 2019;59(11):3452-3463.
Medication Comparisons
Compare medications used to treat Acquired Factor Xiii Deficiency C0238120. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy