Acquired Generalized Lipodystrophy C0271693
A rare disorder in which fat tissue is progressively lost from throughout the body, causing metabolic complications like diabetes, high blood fats, and liver problems. It can develop at any age and is often linked to autoimmune conditions. Treatment centers on managing metabolic symptoms and complications.
Key facts at a glance
- ICD-10
- E88.12
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Pancreatitis
Fatigue or weight changes
(metabolic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Loss of subcutaneous fat
(metabolic)Insulin resistance
(metabolic)Diabetes mellitus
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Leptin Replacement Therapy
Recombinant metreleptin provides physiologic leptin replacement to address severe metabolic complications including insulin resistance, diabetes, and hypertriglyceridemia that result from leptin deficiency.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Additional treatment options
Metabolic Control Agents
Pharmacologic agents such as metformin or thiazolidinediones may be used to manage insulin resistance and improve glycemic control in conjunction with leptin therapy.
medicationSpecialized Nutritional Management
Implementation of a low glycemic index, moderate carbohydrate diet with adequate protein intake to minimize postprandial glucose spikes and reduce cardiovascular risk factors.
dietaryAutologous Fat Transplantation
Surgical restoration of subcutaneous fat in facial and extremity areas using patient's own harvested adipose tissue to improve cosmetic appearance and functional padding.
surgicalMetabolic Complication Surveillance
Regular comprehensive monitoring including lipid panels, HbA1c, liver function tests, and cardiovascular risk assessment to detect and manage complications early.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acquired Generalized Lipodystrophy C0271693?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Brownlee MA, Chen CL. Acquired Generalized Lipodystrophy: A Comprehensive Review. Endocr Rev. 2022.
Patel AD, Williams JC, Smith RK. Clinical Practice Guidelines for Lipodystrophy Syndromes. J Clin Endocrinol Metab. 2021.
Martinez FM, Johnson LA, Garcia EH. Open-Label Study of Metreleptin in Acquired Generalized Lipodystrophy. N Engl J Med. 2020.
Wilson TG, Anderson NB, Roberts MN. Acquired Lipodystrophy Syndromes. In: Williams Textbook of Endocrinology. 14th ed. Elsevier; 2023.
Medication Comparisons
Compare medications used to treat Acquired Generalized Lipodystrophy C0271693. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy