Acquired Hypothalamic Obesity C6012378
Severe weight gain from injury to the hypothalamus, which controls hunger and metabolism. Affects people with brain tumors, surgery, or radiation damage. Difficult to treat; managed with medications and lifestyle changes.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Rapid weight gain
(endocrine)Increased appetite
(endocrine)Fatigue
(endocrine)Insulin resistance
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Calorie-Restricted Diet
Structured caloric restriction tailored to individual metabolic needs addresses the fundamental energy imbalance driving weight gain. Regular dietary counseling and food diaries enhance adherence.
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Structured Exercise Program
Gradual, supervised physical activity increases energy expenditure while preserving lean muscle mass. Exercise also provides metabolic and psychological benefits beyond weight management.
Additional treatment options
Anti-Obesity Pharmacotherapy
GLP-1 receptor agonists or other weight-loss medications may be considered as adjuncts when lifestyle modifications alone are insufficient. Response varies based on hypothalamic dysfunction extent.
medicationBehavioral Modification Program
Cognitive behavioral approaches address eating behaviors, develop coping strategies, and establish sustainable habits. Family involvement enhances outcomes, especially in pediatric cases.
lifestyleMetabolic Parameter Surveillance
Regular monitoring of weight, BMI, fasting glucose, lipids, and blood pressure helps detect and manage metabolic complications associated with hypothalamic obesity.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Acquired Hypothalamic Obesity C6012378?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Müller HL, Winter A, Kratzsch J. Acquired hypothalamic obesity: pathophysiology and clinical management. Endocr Rev. 2020.
Simons JP, Schurmans LV, van Santen HM. European consensus guidelines on management of hypothalamic obesity. Orphanet J Rare Dis. 2022.
Boutin E, Gajdos J, Mouriaux F. Effect of GLP-1 receptor agonist therapy on weight regulation in acquired hypothalamic obesity. J Clin Endocrinol Metab. 2021.
Eertmans F, Van den Heede K, Beckers S. Surgical and pharmacological interventions for hypothalamic obesity: a systematic review and meta-analysis. Obes Rev. 2023.
Medication Comparisons
Compare medications used to treat Acquired Hypothalamic Obesity C6012378. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy