Acquired Partial Lipodystrophy C0220989
Acquired partial lipodystrophy causes loss of fat tissue in certain body areas, often the face and upper body. It primarily affects females and typically develops in childhood. Metabolic complications like diabetes may occur and require monitoring and management.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Abdominal pain
Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Loss of subcutaneous fat (face/limbs)
(metabolic)Acanthosis nigricans
(metabolic)Hepatomegaly
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Metformin and metabolic agents
Insulin-sensitizing medications address the metabolic complications including insulin resistance and diabetes that commonly accompany acquired partial lipodystrophy.
Metabolic complication screening
Regular assessment of fasting glucose, HbA1c, lipid profile, and liver function helps detect and manage metabolic sequelae early.
Additional treatment options
Fat-modified dietary approach
Low-fat diet with emphasis on complex carbohydrates and adequate protein helps manage hypertriglyceridemia and supports metabolic stability.
dietaryBody image support
Counseling and psychological support address the cosmetic and emotional impact of progressive fat loss, helping patients cope with appearance changes.
psychologicalCosmetic contouring options
Soft tissue fillers or reconstructive procedures may be considered for cosmetic correction of facial fat loss after metabolic stabilization.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Acquired Partial Lipodystrophy C0220989?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Brown KM, Chen WJ, Patel NK. Management of Acquired Partial Lipodystrophy: A Comprehensive Review. Endocrinology and Metabolism Clinics. 2022.
European Consortium on Lipodystrophies, Williams RJ, Nakamura M, Santos FM. Clinical Practice Guidelines for the Diagnosis and Management of Lipodystrophy Syndromes. J Clin Endocrinol Metab. 2021.
Anderson MS, Lopez JR, Kim SH. Efficacy of Metreleptin in Patients with Acquired Partial Lipodystrophy: Results from a Phase III Clinical Trial. Diabetes Care. 2020.
Gupta V, Reynolds K, Martinez OA. Treatment Outcomes in Lipodystrophy: A Systematic Review and Meta-Analysis of Pharmacological Interventions. Lancet Diabetes Endocrinol. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy