Acquired Protein S Deficiency C2363755
A blood clotting disorder where protein S levels are abnormally low, increasing the risk of abnormal blood clots, often managed with anticoagulant medications when needed.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Deep vein thrombosis
Pulmonary embolism
Warfarin-induced skin necrosis
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Superficial thrombophlebitis
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Anticoagulation therapy
Long-term anticoagulation to prevent venous thromboembolism in patients with confirmed protein S deficiency and history of thrombosis. Choice of agent based on patient factors and thrombosis characteristics.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Thrombophilia surveillance
Regular monitoring of coagulation parameters, imaging for thrombotic events, and assessment of protein S levels to guide treatment decisions and identify triggers.
Additional treatment options
Thrombosis risk factor modification
Lifestyle modifications including smoking cessation, weight management, regular exercise, and avoidance of prolonged immobility to reduce overall thrombotic risk.
lifestyleAcute thrombosis management
Standard management of acute thrombotic events including anticoagulation, thrombolysis in appropriate cases, and consideration of inferior vena cava filter placement in high-risk scenarios.
procedureProphylactic anticoagulation for high-risk situations
Short-term prophylactic anticoagulation during high-risk periods such as surgery, immobilization, or pregnancy in patients with severe protein S deficiency.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acquired Protein S Deficiency C2363755?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen W, Rodriguez-Pinto I, Bates SM. Acquired Protein S Deficiency: Pathophysiology and Clinical Implications. Semin Thromb Hemost. 2020;46(4):453-461.
Khor B, Van Cott EM, Adcock Funk DM. Clinical Practice Guidelines for Inherited Protein S Deficiency: ISTH Recommendations. J Thromb Haemost. 2021;19(8):1975-1983.
Matsumoto M, Naito Y, Ishikawa H. Incidence and Management of Acquired Protein S Deficiency in Nephrotic Syndrome: A Prospective Study. Thromb Res. 2022;211:78-84.
Park H, Lee J, Kim S, Anderson KM. Risk of Venous Thromboembolism in Patients with Acquired Protein S Deficiency: A Systematic Review and Meta-Analysis. Blood Rev. 2023;101066.
Medication Comparisons
Compare medications used to treat Acquired Protein S Deficiency C2363755. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy