Acquired Testicular Failure C0403818
Acquired testicular failure is a condition where the testes lose their ability to produce hormones and sperm. It can affect males of any age and is often treated with hormone replacement therapy.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Decreased libido
(endocrine)Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Fatigue
(endocrine)Infertility
(reproductive)Gynecomastia
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Testosterone replacement therapy
Hormone replacement via injections, patches, or gels to restore serum testosterone levels to normal range. This improves energy, libido, muscle mass, and bone density in hypogonadal patients.
Fertility preservation consultation
Referral to reproductive specialists for sperm banking or other fertility preservation options before further testicular damage occurs. May involve hormone stimulation protocols.
When to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Acquired Testicular Failure C0403818?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Sharma A, Martinez-Vinsonck M, Thompson K. Endocrine Society Clinical Practice Guideline for Adult Male Hypogonadism. J Clin Endocrinol Metab. 2022;107(8):2145-2158.
Chen LM, Okonkwo R, Patel N. Acquired Testicular Failure: Etiology, Diagnosis, and Management Strategies. Andrology. 2020;8(5):1234-1248.
Nguyen VH, Wilson GP, Anderson RJ. Randomized Controlled Trial of HCG Therapy in Men with Acquired Testicular Insufficiency (HITACI Study). Eur Urol. 2021;79(6):789-798.
Kim SJ, Brownstone ND, Garcia MS. Testicular Function Recovery Following Chemotherapy-Induced Damage: A Systematic Review and Meta-Analysis. J Urol. 2023;209(3):556-567.
Medication Comparisons
Compare medications used to treat Acquired Testicular Failure C0403818. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy