Acquired Von Willebrand Syndrome C0272362
A bleeding disorder where the body produces antibodies against von Willebrand factor, affecting clotting. Usually occurs in adults with other conditions like autoimmune disease or cancer. Treatment aims to control bleeding and manage the underlying disease.
Key facts at a glance
- ICD-10
- D68.04
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Prolonged postoperative bleeding
Epistaxis
(hematologic)Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Easy bruising
(hematologic)Menorrhagia
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Desmopressin acetate
Synthetic hormone that stimulates release of stored von Willebrand factor from endothelial cells, increasing factor levels temporarily. Can be given intranasally, orally, or intravenously for bleeding episodes or surgical prophylaxis.
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Von Willebrand factor concentrate
Intravenous infusion of plasma-derived VWF concentrates for major bleeding, surgery, or delivery. Provides direct replacement of deficient factor.
When to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Acquired Von Willebrand Syndrome C0272362?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Federici AB, Nichols TC, Mannucci PM. Guidelines for the diagnosis and management of acquired von Willebrand syndrome in adults. J Thromb Haemost. 2020;18(9):2116-2125.
Mital A, Lillicrap D, Wolff S. Acquired von Willebrand disease: pathophysiology and clinical management. Blood Rev. 2019;33(1):45-55.
Budde U, Schneppenheim R, Hesse V. Laboratory diagnosis of acquired von Willebrand syndrome: a prospective multicenter study. Haemophilia. 2021;27(4):642-651.
Karger R, Huter S, Eifrig B. Acquired von Willebrand syndrome in lymphoproliferative disorders: a retrospective analysis of 85 patients. Thromb Haemost. 2018;119(7):1123-1132.
Medication Comparisons
Compare medications used to treat Acquired Von Willebrand Syndrome C0272362. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy