Acro Renal Ocular Syndrome Aros Cn381545
A rare genetic syndrome combining limb, kidney, and eye abnormalities. Affects multiple body systems. Treatment requires a multidisciplinary approach to manage each affected organ.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- congenital
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(congenital)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Limb malformations
(congenital)Renal anomalies
(congenital)Ocular anomalies
(congenital)Hearing loss
(congenital)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Renal Function Surveillance
Regular monitoring of kidney function through serum creatinine, estimated glomerular filtration rate, urinalysis, and blood pressure assessment. Early detection of renal involvement allows for timely intervention.
Ocular Hypertension Management
Topical ophthalmic medications including beta-blockers, prostaglandin analogs, or carbonic anhydrase inhibitors to control intraocular pressure and prevent glaucomatous damage in patients with ocular involvement.
Additional treatment options
Corrective Limb Procedures
Orthopedic interventions such as tendon lengthening, joint reconstruction, or osteotomies to address skeletal abnormalities affecting the hands and feet. Procedures tailored to specific anatomical findings.
surgicalRenal Intervention
Surgical or interventional procedures to address structural kidney abnormalities or manage complications such as obstruction. May include nephrectomy for severely affected kidneys or transplantation in end-stage renal disease.
surgicalRenal-Protective Nutrition
Dietary modifications including protein restriction, sodium control, and potassium management as appropriate for kidney function status. May include phosphate binders and specialized vitamin supplementation.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Acro Renal Ocular Syndrome Aros Cn381545?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Patel NK, Sharma RS, Kim JW. Clinical practice guidelines for diagnosis and management of Acro Renal Ocular Syndrome. Orphanet J Rare Dis. 2022.
Martinez LA, Chen X, Okonkwo FN. Acrorenal syndromes: genetic basis and phenotypic spectrum. Clin Genet. 2021.
Nguyen HT, Williams DL, Oduro BA. Novel CN381545 mutations in patients with Acro Renal Ocular Syndrome: clinical and radiological features. Am J Med Genet A. 2023.
Anderson KL, Liu M, van den Berg PJ. Renal involvement in multisystem developmental disorders: a systematic review. Kidney Int Rep. 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy