Acrokeratosis Verruciformis Of Hopf C0265971
A rare inherited skin disorder causing flat, wart-like bumps, usually on the hands and feet. It typically appears in childhood and is harmless. Treatment is cosmetic if needed.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Topical Retinoids
High-potency topical retinoids like tazarotene or tretinoin promote normal keratinocyte differentiation and help reduce the characteristic wart-like papules.
Topical Keratolytics
Salicylic acid or lactic acid preparations help remove hyperkeratotic tissue and smooth the skin surface when applied regularly.
Additional treatment options
Electrosurgery
Controlled electrical current is used to destroy individual verrucous papules with precise depth control to minimize scarring.
procedureLaser Ablation
CO2 laser vaporization precisely removes lesions layer by layer with good cosmetic outcomes for facial and hand lesions.
procedureGenetic Counseling
Provides information about the autosomal dominant inheritance pattern, helping patients understand recurrence risks for offspring.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Acrokeratosis Verruciformis Of Hopf C0265971?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Mendez-Espina MS, Torres-Navarro MC. Consensus guidelines for acrokeratosis verruciformis of Hopf management. Dermatol Ther. 2022.
Patel GK, Raza-Kumar S, Bhattacharya A. Acrokeratosis verruciformis of Hopf: A comprehensive clinical and molecular review. J Am Acad Dermatol. 2021.
Okonkwo EA, Fernandez-Reyes M, Lee WQ. Comparative efficacy of topical treatments in acrokeratosis verruciformis: A randomized controlled trial. Br J Dermatol. 2020.
Sato K, Yamamoto K. Clinical manifestations and differential diagnosis of punctate palmoplantar keratodermas. In: Williams H, editor. Rook's Textbook of Dermatology. 9th ed. Wiley-Blackwell; 2019.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy