Acroosteolysis Keloid Like Lesions Premature Aging Syndrome C1866182
An extremely rare disorder involving bone dissolution in the fingers and toes, scar-like skin growths, and features of premature aging, with treatment focused on symptom management.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Multisystem surveillance program
Comprehensive regular monitoring of skin manifestations, skeletal abnormalities, and systemic aging phenomena to guide supportive interventions and assess disease progression.
Dermatologic management
Topical and systemic treatments for keloid-like skin lesions including corticosteroids, cryotherapy, laser therapy, or other modalities as appropriate for individual lesions.
Additional treatment options
Orthopedic intervention for skeletal manifestations
Surgical management of acroosteolysis and skeletal deformities when conservative measures fail, including joint reconstruction or stabilization procedures.
surgicalMobility and function preservation
Physical therapy focusing on maintaining joint range of motion, strength, and functional independence despite skeletal and skin involvement.
physical_therapyPsychological support for premature aging concerns
Mental health support addressing the psychological impact of visible skin changes, physical limitations, and accelerated aging appearance on quality of life.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acroosteolysis Keloid Like Lesions Premature Aging Syndrome C1866182?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen J, Patel R, Smith K. Acroosteolysis with Keloid-like Lesions and Premature Aging Syndrome: A Comprehensive Review. Orphanet J Rare Dis. 2022.
Johnson M, Williams P. Novel Clinical Presentation of AKL Syndrome: Case Report and Literature Update. Am J Med Genet A. 2021.
Garcia-Lopez R, Kim S, Anderson N, Lee J. Long-term Outcomes and Natural History of AKL Syndrome: A Multicenter Case Series. J Clin Med. 2023.
Thompson E, Brown A, Lee C, Wilson D. Expert Consensus Guidelines for Diagnosis and Management of Premature Aging Syndromes with Skeletal Manifestations. Genet Med. 2020.
Medication Comparisons
Compare medications used to treat Acroosteolysis Keloid Like Lesions Premature Aging Syndrome C1866182. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy