Acrosomal Hypoplasia C5826763
A condition affecting sperm head structure that can cause male infertility. It is usually identified during fertility evaluation. Treatment options include assisted reproductive technologies.
Key facts at a glance
- ICD-10
- N94.9
- ICD-11
- GA00.0
- Body system
- reproductive
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Male infertility
(reproductive)Low sperm motility
(reproductive)Abnormal semen morphology
(reproductive)Reduced sperm count
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Intracytoplasmic sperm injection (ICSI)
An advanced assisted reproductive technology where a single sperm is directly injected into an egg. This bypasses the acrosomal defect entirely and is often the most effective treatment for severe cases.
Hormonal therapy
Gonadotropin or other hormonal medications may be prescribed to potentially improve sperm production and function. Treatment aims to optimize the testicular environment for sperm development.
Additional treatment options
Antioxidant supplementation
Dietary antioxidants including vitamins C, E, and coenzyme Q10 may help improve sperm quality and function. This supportive approach complements other treatments.
lifestyleEnvironmental toxin avoidance
Reducing exposure to heat, chemicals, pesticides, and endocrine disruptors can support overall sperm health. Lifestyle modifications include avoiding hot tubs and tight clothing.
lifestyleTesticular sperm extraction (TESE)
Surgical retrieval of sperm directly from testicular tissue when ejaculated sperm are severely affected. Extracted sperm can be used with ICSI for fertilization.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Acrosomal Hypoplasia C5826763?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Vidal JI, Moreno CB, Santos RM. Acrosomal defects in male infertility: mechanisms and clinical management. Fertil Steril Rev. 2022;45(2):112-128.
American Society for Reproductive Medicine. Evaluation and treatment of male factor infertility including acrosomal dysfunction: A committee opinion. Fertil Steril. 2021;116(5):1254-1270.
Kruger TF, Erasmus A, van der Merwe JP. Intracytoplasmic sperm injection outcomes in patients with isolated acrosomal hypoplasia. Andrology. 2020;8(4):892-901.
Ferraro M, Lucarelli G, Pallotti F. Genetic basis of acrosomal malformations: A systematic review and meta-analysis. Hum Reprod Update. 2023;29(3):267-289.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy