Acth Dependent Cushing Syndrome C0342442
A hormonal disorder caused by excess ACTH production, usually from a pituitary tumor, leading to high cortisol levels. Typically affects adults. Treatment often involves removing the tumor causing the excess hormone.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Central obesity
(endocrine)Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Moon face
(endocrine)Proximal muscle weakness
(endocrine)Hypertension
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Transsphenoidal Pituitary Surgery
Endoscopic removal of ACTH-secreting pituitary adenoma as primary curative approach for Cushing disease when a discrete tumor is identified.
Steroidogenesis Inhibitor Therapy
Medications such as ketoconazole, metyrapone, or etomidate that block cortisol production by the adrenal glands.
Additional treatment options
Bilateral Adrenalectomy
Surgical removal of both adrenal glands to eliminate cortisol excess when other treatments fail or are contraindicated.
surgicalPituitary-Directed Medical Therapy
Pasireotide or other agents targeting the pituitary tumor to suppress ACTH secretion.
medicationMetabolic Complications Management
Multidisciplinary management including glycemic control, hypertension management, bone health preservation, and infection prevention.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Acth Dependent Cushing Syndrome C0342442?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Nieman LK, Biller BMK, Findling JW, Murad MH, Newell-Price J, Savage MO, Tabarin A. Treatment of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2015;100(8):2807-2831.
Lacroix A, Feelders RA, Stratakis CA, Nieman LK. Cushing's Syndrome. Lancet. 2015;386(9996):913-927.
Ding D, Liu H, Guo D, Dong L, Yu D. Surgical Outcomes of Transsphenoidal Surgery for Cushing's Disease: A Systematic Review and Meta-Analysis. Neurosurgery. 2021;88(3):526-537.
Shahid RK, Mughal A, Ahmed R, Ali A. Ectopic ACTH Syndrome: Challenges in Diagnosis and Management. Endocrine. 2020;68(2):304-313.
Medication Comparisons
Compare medications used to treat Acth Dependent Cushing Syndrome C0342442. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy