Acth Independent Adrenal Cushing Syndrome Somatic Cn322664
Cushing syndrome arising from a tumor in the adrenal gland itself that produces excess cortisol. Usually occurs in adults. Surgical removal of the tumor often leads to improvement or cure.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Central obesity
(endocrine)Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hypertension
(endocrine)Hyperglycemia
(endocrine)Skin striae
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Unilateral Adrenalectomy
Surgical removal of the affected adrenal gland is the primary treatment for unilateral ACTH-independent adrenal Cushing syndrome. This procedure is typically performed using minimally invasive techniques such as laparoscopy, resulting in resolution of hypercortisolism in most cases.
Additional treatment options
Adrenal-Directed Pharmacotherapy
Medications that inhibit cortisol synthesis, such as ketoconazole, metyrapone, or mitotane, may be used when surgery is contraindicated or as bridge therapy. These agents work by targeting enzymes involved in adrenal cortisol production.
medicationGlucocorticoid Receptor Antagonist
Mifepristone blocks the effects of cortisol at the receptor level and may be used in select cases where cortisol synthesis inhibitors are ineffective or not tolerated. Patients require careful monitoring for hypokalemia and endometrial thickening.
medicationActive Surveillance
For patients with mild autonomous cortisol secretion and minimal symptoms, regular monitoring of cortisol levels, blood pressure, glucose metabolism, and bone density may be appropriate. Intervention is initiated if clinical deterioration occurs.
monitoringComorbidities Management
Concurrent management of cortisol excess complications including glycemic control, hypertension management, bone health preservation, and cardiovascular risk reduction through lifestyle modifications and appropriate medications.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Acth Independent Adrenal Cushing Syndrome Somatic Cn322664?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Nieman LK, Biller BM, Findling JW, et al. Treatment of Cushing's syndrome: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2015.
Lacroix A, Feelders RA, Stratakis CA, Nieman LK. Cushing's syndrome. Lancet. 2015.
Faggiano A, Pivonello R, Spiezia S, et al. Cardiovascular risk and quality of life in Cushing's syndrome: A prospective study. Eur J Endocrinol. 2016.
Gazzaneo V, Fichera M, Barca MF, et al. Adrenalectomy versus conservative management for ACTH-independent adrenal Cushing's syndrome: A systematic review and meta-analysis. Surgery. 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy