Acth Independent Macronodular Adrenal Hyperplasia 3 C5975485
A genetic variant of bilateral adrenal hyperplasia where nodules produce cortisol independently of ACTH, leading to hypercortisolism. Usually diagnosed in adults. Management includes cortisol-lowering drugs or adrenal gland removal surgery.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Central obesity
(endocrine)Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Proximal muscle weakness
(endocrine)Osteoporosis
(endocrine)Hirsutism
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Bilateral Adrenalectomy
Surgical removal of both adrenal glands to eliminate cortisol overproduction. This is the definitive treatment for ACTH-independent macronodular adrenal hyperplasia and results in cure of hypercortisolism.
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Additional treatment options
Steroidogenesis Inhibitors
Medical therapy using adrenal enzyme inhibitors such as ketoconazole, metyrapone, or mitotane to reduce cortisol production when surgery is contraindicated or as bridge therapy.
medicationRegular Endocrine Surveillance
Periodic monitoring of cortisol levels, adrenal imaging, and metabolic markers to assess disease progression and determine optimal timing for surgical intervention.
monitoringMetabolic Complication Management
Comprehensive management including blood pressure control, diabetes management, and bone health maintenance to address complications of hypercortisolism.
lifestylePsychological Support
Counseling and psychological support to address mood disorders, cognitive changes, and quality of life issues associated with chronic hypercortisolism.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Acth Independent Macronodular Adrenal Hyperplasia 3 C5975485?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Nieman LK, Biller BM, Findling JW, et al. Treatment of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2015;100(8):2807-2831.
Elias PC, Lima EN, Machado MC, et al. ACTH-Independent Macronodular Adrenal Hyperplasia: Clinical and Molecular Characteristics. Endocr Rev. 2020;41(2):245-269.
Faucz FR, Zilbermint M, Lodish MB, et al. Armadillo Repeat Containing 5 (ARMC5) Mutations in Primary Macronodular Adrenal Hyperplasia. J Clin Endocrinol Metab. 2014;99(6):E1131-E1140.
Lacroix A, Bourdeau I, Lampron A, et al. Aberrant G-Protein Coupled Receptor Expression in Adrenocortical Hyperplasia and Adenomas. Mol Cell Endocrinol. 2013;371(1-2):141-147.
Medication Comparisons
Compare medications used to treat Acth Independent Macronodular Adrenal Hyperplasia 3 C5975485. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy