Acth Producing Pituitary Gland Carcinoma C1334556
A rare pituitary cancer that produces excess stress hormones. Treatment typically involves surgery, radiation, and medications to control hormone levels.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Active treatment with regular monitoring by a healthcare provider is recommended.
Transsphenoidal surgery for tumor resection
Endoscopic or microscopic transsphenoidal surgery to remove the ACTH-secreting pituitary carcinoma, considered the primary treatment modality when tumor is resectable.
Steroidogenesis inhibitors and hormonal therapy
Medical management using adrenal enzyme inhibitors such as ketoconazole, metyrapone, or mitotane to reduce cortisol production and control Cushing syndrome manifestations.
Additional treatment options
Stereotactic radiosurgery
Focused radiation therapy targeting residual or recurrent pituitary tumor tissue, particularly when surgery is contraindicated or incomplete resection occurred.
procedurePasireotide somatostatin analog therapy
Pasireotide, a somatostatin receptor multi-agonist, may reduce ACTH secretion and tumor growth in selected cases of ACTH-producing pituitary tumors.
medicationBilateral adrenalectomy
Surgical removal of both adrenal glands as a definitive treatment for refractory hypercortisolism when other approaches fail, eliminating Cushing syndrome.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acth Producing Pituitary Gland Carcinoma C1334556?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Meningioma Consortium Group. Management of Pituitary Carcinomas and Aggressive Pituitary Tumors: Clinical Practice Guidelines. Endocr Rev. 2022.
Shimon I, Fleseriu M, Buchfelder M. ACTH-Secreting Pituitary Carcinomas: From Bench to Bedside. Pituitary. 2021.
Beckers A, Dalanta N, Korbonits M. Long-term Outcomes of Aggressive Pituitary Tumors Treated with Temozolomide: A Prospective Study. J Clin Endocrinol Metab. 2020.
Cuevas-Ramos D, Carmichael JD, Cooper O. Surgical Outcomes and Prognostic Factors in ACTH-Producing Pituitary Carcinomas: Systematic Review and Meta-Analysis. Neuroendocrinology. 2019.
Medication Comparisons
Compare medications used to treat Acth Producing Pituitary Gland Carcinoma C1334556. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy