Acth Producing Pituitary Gland Neoplasm C0278862
A tumor of the pituitary gland that produces ACTH, leading to excessive cortisol levels and associated health problems. Can affect adults. Treatment options include surgical removal, radiation therapy, or medications to reduce cortisol production.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Optic chiasm compression
Cushing syndrome
(endocrine)Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hypopituitarism
(endocrine)Severe fatigue
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Complete Tumor Resection
Maximal safe surgical resection of ACTH-producing pituitary neoplasm, typically via transsphenoidal or transcranial approach depending on tumor extent and invasiveness.
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Additional treatment options
Adjuvant Radiation Therapy
Postoperative radiation to reduce recurrence risk in aggressive ACTH-producing pituitary neoplasms. May be conventional or stereotactic approach.
procedureSystemic Medical Therapy
Chemotherapy agents including temozolomide for aggressive or malignant ACTH-producing pituitary neoplasms resistant to surgery and radiation.
medicationACTH-Suppressing Agents
Adrenal-blocking medications such as ketoconazole, metyrapone, or etomidate to control hypercortisolism symptoms in aggressive disease.
medicationLong-Term Surveillance Imaging
Regular MRI imaging and biochemical monitoring for early detection of recurrence or progression in ACTH-producing pituitary neoplasms.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Acth Producing Pituitary Gland Neoplasm C0278862?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Nieman LK, Biller BM, Findling JW, et al. Treatment of Cushing's syndrome: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2015.
Pivonello R, De Leo M, Cozzolino A, Colao A. The Treatment of Cushing's Disease: A Meta-Analysis of Surgical Outcomes. Endocr Rev. 2018.
Fleseriu M, Biller BM, Findling JW, et al. Osilodrostat, an Oral 11β-Hydroxylase Inhibitor, in Cushing's Disease: Results from a Prospective Trial. J Clin Endocrinol Metab. 2021.
Lonser RR, Nieman L, Oldfield EH. Cushing's Disease: Pathobiology and Endoscopic Surgical Management. Neurosurg Clin N Am. 2023.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy