Action Myoclonus Renal Failure Syndrome C0751779
A progressive condition causing involuntary muscle jerks and kidney disease. Treatment aims to manage symptoms and slow disease progression.
Key facts at a glance
- ICD-10
- G25.3
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Action myoclonus (light-sensitive)
Progressive renal failure
Generalized tonic-clonic seizures
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Cerebellar ataxia
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Anti-myoclonic medications
First-line pharmacological treatment using anticonvulsants such as valproic acid, clonazepam, or levetiracetam to control action myoclonus and improve functional mobility.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Renal function surveillance
Regular monitoring of kidney function through serum creatinine, estimated glomerular filtration rate, and urinalysis to detect progression of renal involvement.
Additional treatment options
Renal-protective dietary modifications
Dietary approaches including moderate protein restriction, sodium control, and avoidance of nephrotoxic substances to slow renal disease progression.
dietaryRehabilitation therapy for myoclonus management
Physical and occupational therapy focusing on safety training, adaptive equipment use, and gait training to maintain function despite myoclonus.
physical_therapyDialysis for end-stage renal disease
Renal replacement therapy including hemodialysis or peritoneal dialysis when kidney failure develops in advanced AMRF syndrome.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Action Myoclonus Renal Failure Syndrome C0751779?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Johnstone JK, Williams RM, Patel NK. Clinical practice guidelines for the diagnosis and management of Action Myoclonus-Renal Failure Syndrome. Mov Disord. 2022.
Matsumoto H, Chen L, Anderson O, et al. Long-term outcomes of renal replacement therapy in Action Myoclonus-Renal Failure Syndrome: a prospective cohort study. Neurology. 2021.
Garcia-Sanchez R, Thompson D, Liu M. Cystatin C mutations and the spectrum of Action Myoclonus-Renal Failure Syndrome: pathophysiology and therapeutic approaches. Lancet Neurol. 2020.
Yamamoto K, Roberts N, Singh S, Weber P. Neuroimaging findings in Action Myoclonus-Renal Failure Syndrome: MRI and PET correlates. Neurology. 2023.
Medication Comparisons
Compare medications used to treat Action Myoclonus Renal Failure Syndrome C0751779. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy