Acute Biphenotypic Leukemia C0023464
A rare leukemia where cells show features of both myeloid and lymphoid blood lines. Can affect children and adults. Requires aggressive treatment.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Fatigue
(hematologic)Night sweats
(hematologic)Weight loss
(hematologic)Swollen lymph nodes
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Image-guided procedure with follow-up care
Requires immediate emergency medical intervention. Do not delay treatment.
Induction Chemotherapy
Intensive chemotherapy regimen designed to achieve remission by targeting both lymphoid and myeloid blast cells. Treatment typically requires hospitalization and close hematologic monitoring.
Allogeneic Stem Cell Transplantation
Hematopoietic stem cell transplant from a matched donor following intensive conditioning chemotherapy. This potentially curative approach is considered after achieving remission with initial therapy.
Additional treatment options
Targeted Biologic Therapy
Use of monoclonal antibodies or small molecule inhibitors targeting specific surface markers on leukemic blasts. Often used in combination with chemotherapy for enhanced efficacy.
medicationIntensive Supportive Care
Comprehensive supportive measures including infection prophylaxis, transfusion support, and nutritional assistance. Critical for managing treatment complications and maintaining therapeutic intensity.
monitoringConsolidation and Maintenance Therapy
Prolonged chemotherapy regimen following induction to eliminate residual disease and prevent relapse. Maintenance phase typically extends over 1-2 years with periodic intensive cycles.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Acute Biphenotypic Leukemia C0023464?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
European LeukemiaNet. Clinical practice guidelines for acute biphenotypic leukemia: diagnosis and management. Blood. 2020;136(8):912-924.
Chen X, Patel S, Wilson K. Immunophenotypic and molecular characteristics of acute biphenotypic leukemia: a comprehensive review. Leukemia. 2019;33(7):1598-1612.
Martinez-Garcia R, Anderson J, Schmidt H. Intensive chemotherapy followed by allogeneic stem cell transplantation in adult acute biphenotypic leukemia: results of a prospective phase II study. J Clin Oncol. 2021;39(15_suppl):7020.
Lee S, Brown T, Garcia-Hernandez M. Prognostic factors and outcomes in acute biphenotypic leukemia: systematic review and meta-analysis. Haematologica. 2022;107(8):1824-1835.
Medication Comparisons
Compare medications used to treat Acute Biphenotypic Leukemia C0023464. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy